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MetabolomicsMitochondrial NAD+ Deficiency in Vascular Smooth Muscle Impairs Collagen III Turnover to Trigger Aortic Disease

Aortic disease poses a significant mortality risk in adults, yet many of its underlying factors remain undiscovered. In this study, we identify mitochondrial NAD⁺ deficiency as a causal factor. Metabolomics analysis of 73 surgical aortic specimens revealed impaired NAD⁺ salvage and mitochondrial ...

2024-12-04 | MTBLS8062 | MetaboLights
TranscriptomicsCathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
Cavitation in tuberculosis (TB) enables highly efficient person-to-person aerosol transmission. Currently, a number of hypotheses exist regarding the mechanisms underlying this process. To explore this process, we undertook an unbiased next-generation transcriptional analysis of samples from cavity ...
ORGANISM(S): Oryctolagus cuniculus 
2015-11-03 | E-GEOD-68206 | biostudies-arrayexpress
ProteomicsA Novel High-Throughput Immunoaffinity LC-MS/MS Assay for P III-NP and other Fragments of Type III Procollagen in Human Serum
The amino-terminal propeptide of type III procollagen (P-III-NP) is used with IGF-I to detect the illicit use of growth hormone and to monitor growth hormone therapy. However, the only currently available assays for P-III-NP are immunoassays, which are not well harmonized. In addition, other fragmen...
ORGANISM(S): Homo Sapiens 
2024-10-28 | PXD052245 | panorama
UnknownCollagen turnover during cervical remodeling involves both intracellular and extracellular collagen degradation pathways†.
Not available
S-EPMC11996760 | biostudies-literature
UnknownCollagen turnover profiles in chronic kidney disease.
Not available
S-EPMC6831687 | biostudies-literature
UnknownVariation in Human Bone Collagen Turnover Among Skeletal Elements.
Not available
S-EPMC12820750 | biostudies-literature
UnknownGenetic link between obesity and MMP14-dependent adipogenic collagen turnover.
Not available
S-EPMC3279534 | biostudies-literature
UnknownTurnover rates of hepatic collagen and circulating collagen-associated proteins in humans with chronic liver disease.
Not available
S-EPMC4409311 | biostudies-literature
TranscriptomicsCathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
Cavitation in tuberculosis (TB) enables highly efficient person-to-person aerosol transmission. Currently, a number of hypotheses exist regarding the mechanisms underlying this process. To explore this process, we undertook an unbiased next-generation transcriptional analysis of samples from cavity ...
ORGANISM(S): Oryctolagus cuniculus 
2015-11-03 | GSE68206 | GEO
UnknownCollagen Turnover in Relation to Risk Factors and Hemodynamics in Human Intracranial Aneurysms.
Not available
S-EPMC7340076 | biostudies-literature
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