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Metabolomicsuntargeted metabolomic profiling of colonic contents

Pre-IBD is a transitional state between irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), in which chronic high-fat diet intake and antibiotic exposure significantly increase intestinal inflammatory susceptibility. However, the underlying mechanisms and effective therapeutic st...

2026-04-29 | MTBLS14400 | MetaboLights
TranscriptomicsExpression data from heterotopically grafted mouse small intestinal epithelium and the normal colonic epithelium
Epithelia of small and large intestines differ in their structures and functions. Such heterogeneity between these two epithelial tissues might be controlled by both epithelium-intrinsic and -extrinsic programs. By employing the cell transplantation technique developed in our laboratory, we investig...
ORGANISM(S): Mus musculus 
2014-08-15 | E-GEOD-59410 | biostudies-arrayexpress
TranscriptomicsDifferent levels of canonical Wnt signaling exert distinct roles in the colonic epithelium
There is a gradient of M-NM-2-catenin expression along the colonic crypt axis with the highest levels at the crypt bottom. However, it remains unclear whether different levels of canonical Wnt signaling exert distinct roles in the colonic epithelium. In the present study, we first showed that the ca...
ORGANISM(S): Mus musculus 
2013-01-22 | E-GEOD-41688 | biostudies-arrayexpress
MetabolomicsWLJP-025p Promote Colonic Epithelial Repair in Ulcerative Colitis through Fatty Acid Oxidation by Regulating Microbial-involvemented SPD Production

BACKGROUND & AIMS: Ulcerative colitis (UC) poses a serious threat to human health. WLJP-025p, a polysaccharide component of Lonicera japonica thunb. has been confirmed to have anti-inflammatory and immunomodulatory effects. This study intends to explore the effects and mechanism of WLJP-025p ...

2026-05-16 | MTBLS12400 | MetaboLights
TranscriptomicsIsolation and in vitro expansion of human colonic stem cells
This SuperSeries is composed of the following subset Series: GSE31255: Isolation and in vitro expansion of human colonic stem cells [Expression profile] GSE31256: Isolation and in vitro expansion of human colonic stem cells [CGH] Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31257 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Apc-deficient proximal colonic epithelium upon Msx1 transcription factor depletion
The first step in the development of human colorectal cancer (CRC) is the aberrant hyperactivation of the Wnt signaling pathway, predominantly caused by inactivating mutations in the adenomatous polyposis coli (APC) gene which encodes an essential tumor suppressor. In order to identify genes affecte...
ORGANISM(S): Mus musculus 
2019-11-01 | E-MTAB-6909 | biostudies-arrayexpress
TranscriptomicsGlobal colorectal cancer gene expression in rats
The rat models of colorectal cancer (CRC), such as the azoxymethane (AOM) cancer-inducing model, are important tools for researching cancer initiation pathways. However, there is limited understanding of the expression pathways of underlying normal rat colonic epithelium and how this relates to hum...
ORGANISM(S): Rattus norvegicus 
2010-06-16 | E-GEOD-15184 | biostudies-arrayexpress
TranscriptomicsIsolation and in vitro expansion of human colonic stem cells [CGH]
Tissue for normal colonic stem cell isolation was obtained via colectomy from a colorectal cancer patient. It was shown that the resected tissue and the in vitro-cultured organoids grown from tissue-derived adult stem cells do not harbor chromosomal alterations. For that purpose, genomic DNA from re...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31256 | biostudies-arrayexpress
TranscriptomicsIsolation and in vitro expansion of human colonic stem cells [Expression profile]
Using the surface marker EPHB2, we have FACS-purified and profiled stem cell-enriched cell fractions from normal human mucosa, crypt proliferative progenitors and late transient amplifying cells to define a gene expression program specific for normal human colon epithelial stem cells We FACS purifie...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31255 | biostudies-arrayexpress
GenomicsH3K27ac profiling in control and DSS-treated colonic epithelium
We determined changes in enhancer chromatin that occur during colonic inflammation, found that dynamic chromatin regions are enriched for HNF4A binding motirfs, and then measured HNF4A binidng by ChIP-seq in each condition. Examination of H3K27ac histone modification in normal and DSS-treated colon,...
ORGANISM(S): Mus musculus 
2014-06-30 | E-GEOD-52426 | biostudies-arrayexpress
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