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MetabolomicsATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights
TranscriptomicsComparison of murine colonic mucosal DNA from postnatal day 90 (P90) to postnatal day 30 (P30) by MSAM
DNA methylation profiling of colonic mucosal DNA between P90 and P30 mice. 0.5ug of DNA was serially digested with SmaI and XmaI followed by an adaptor ligation and adaptor mediated PCR amplification Two independent P90 to P30 comparisons were performed as follows. Samples were labelled with Cy3 (P3...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-18031 | biostudies-arrayexpress
ProteomicsProteomic Analysis of rattus norvegicus colonic mucosa following acupuncture treatment for irritable bowel syndrome with diarrhea by label-free LC–MS/MS
To investigate the molecular pathological mechanisms of irritable bowel syndrome with diarrhea (IBS-D) and elucidate the effects of acupuncture on IBS-D colonic mucosa protein abundance in rats, a label-free high-throughput liquid chromatography-tandem mass spectrometry (LC-MS)-based proteomics anal...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-14 | PXD025558 | Pride
Lc-msms Colonic mucosa Rat Acupuncture 
TranscriptomicsGenome wide pathway analysis using gene expression data of colonic mucosa in patients with Inflammatory Bowel Disease
To provide new steps on the role of altered gene expression in the pathogenesis of these diseases, we performed whole gene expression profiling by comparing the RNA from inflamed and non-inflamed colonic mucosa
ORGANISM(S): Homo sapiens 
2014-11-30 | E-MTAB-2967 | biostudies-arrayexpress
TranscriptomicsAltered interactions between the gut microbiome and colonic mucosa precede polyposis in APCMin/+ mice
Mutation of the adenomatous polyposis coli (APC gene), an early event in the adenoma-carcinoma sequence, is present in 70-80% of sporadic human colorectal adenomas and carcinomas. To test the hypothesis that mutation of the APC gene alters microbial interactions with host intestinal mucosa prior to...
ORGANISM(S): Mus musculus 
2015-08-24 | E-GEOD-67634 | biostudies-arrayexpress
Transcriptomicsp38a-dependent gene expression in the colonic mucosa
Gene expression in the colonic mucosa of wild-type and p38a-knockout intestinal epithelial cells (IECs) were compared. C57BL/6 wild-type mice, and intestinal epithelial cell-specific p38a-knockout mice on a C57BL/6 background were used for isolation of colonic mucosa Gene expression in each genotype...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-55356 | biostudies-arrayexpress
TranscriptomicsIsolation and in vitro expansion of human colonic stem cells [Expression profile]
Using the surface marker EPHB2, we have FACS-purified and profiled stem cell-enriched cell fractions from normal human mucosa, crypt proliferative progenitors and late transient amplifying cells to define a gene expression program specific for normal human colon epithelial stem cells We FACS purifie...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31255 | biostudies-arrayexpress
TranscriptomicsImmunoregulatory actions of epithelial cell PPAR g at the colonic mucosa
BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation. The objective of this study was to use a systems approach for investigating the mechanism by which the deletion o...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-20621 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat colonic tumors induced by 1,2-dimethylhydrazine (DMH)
Gene expression analysis of 1,2-dimethylhydrazine (DMH)-induced colon cancer in F344 rats. 9 tumours and their paired normal mucosa were hybridized on 4x44K Agilent Whole rat arrays.
ORGANISM(S): Rattus norvegicus 
2010-07-20 | E-MEXP-2471 | biostudies-arrayexpress
TranscriptomicsExon-level expression profiling of normal colonic mucosa samples.
These samples have been analyzed for global alternative splicing variation on exon-level expression data using the FIRMA algorithm. We have identified and described transcriptome instability as a genome-wide, pre-mRNA splicing related characteristic of solid cancers. This Series consists of 19 norma...
ORGANISM(S): Homo sapiens 
2014-08-13 | E-GEOD-42690 | biostudies-arrayexpress
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