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ProteomicsColonic proteome signature in immunoproteasome-deficient stressed mice and its relevance for irritable bowel syndrome
A role for immunoproteasome in the regulation of intestinal permeability has been previously suggested both in mice during water avoidance stress (WAS) and in patients with irritable bowel syndrome (IBS). We thus aimed (i) to evaluate the colonic proteome in wild-type (wt) and β2i immunoproteasome s...
ORGANISM(S): Mus musculus (Mouse) 
2018-12-05 | PXD011199 | Pride
Colonic proteome  immunoproteasome  irritable bowel syndrome  water avoidance stress. 
ProteomicsRat colon LC-MSMS - Intake of Fish Oil Specifically Modulates Colonic Muc2 Expression in Middle-Aged Rats by Suppressing the Glycosylation Process
Dietary fats have been shown to affect gut microbiota composition and aging gene transcription of middle-aged rats at a normal dose, but little is known about such an effect on gut barrier. In colon, the main component of mucus layer is Muc2, produced by the goblet cells. This study investigated the...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-01-02 | PXD007229 | Pride
Lc-msms Rat Colon 
UnknownImpact of clostridial glucosylating toxins on the proteome of colonic cells determined by isotope-coded protein labeling and LC-MALDI.
Not available
S-EPMC3176154 | biostudies-literature
ProteomicsMetaproteomics of colonic microbiota unveils discrete protein functions among colitic mice and control groups
We utilized the well-characterized murine T cell transfer model of colitis to find specific alterations in the intestinal luminal proteome associated with inflammation. Mass spectrometry proteomic analysis of colonic samples permitted the identification of ~10,000-12,000 unique peptides that corre...
ORGANISM(S): human gut metagenome 
2018-07-05 | PXD006384 | Pride
Metaproteomics Mudpit 16s sequencing Rag1 -/- Microbiota Compil Murine colitis Inflammatory bowel disease T cell transfer 
ProteomicsThe Biochemical Effects of Carotenoids in Orange Carrots on the Colonic Proteome in a Mouse Model of Diet-induced Obesity
Carotenoids are naturally occurring pigments in plants responsible for the orange, yellow, and red color of fruits and vegetables. Carrots are one of the primary dietary sources of carotenoids. The biological activities of carotenoids in higher organisms are well documented in most tissues but not t...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-04 | PXD054150 | Pride
Carotenoids  quantitative proteomics  colon  intestinal barrier  diet-induced obesity 
ProteomicsMembrane proteomis profile along human colon
The colonic epithelium is a highly dynamic system important for regulation of ion and water homeostasis via absorption and secretion, and in maintaining a protective barrier between the outer milieu and the inside of our body. These processes are known to gradually change along the length of the col...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-07 | MSV000079561 | MassIVE
UnknownEffects of Prebiotics Inulin and Oat β-Glucan on Colonic Architecture and Hepatic Proteome in Mice with Circadian-Disruption-Aggravated Metabolic Dysfunction-Associated Steatohepatitis.
Not available
S-EPMC12251635 | biostudies-literature
TranscriptomicsModulation of colonic inflammation in Mdr1a-/- mice by green tea polyphenols and their effects on the colon transcriptome and proteome
This study tested the anti-inflammatory potential of a green tea extract rich in polyphenols (GrTP) in the colon of the multi-drug resistance targeted mutation (Mdr1a-/-) mouse model of IBD. A colonic histological injury score was determined for each mouse to establish the effect of GrTP on inflamma...
ORGANISM(S): Mus musculus 
2012-10-18 | GSE41644 | GEO
UnknownProteome analysis of the macroscopically affected colonic mucosa of Crohn's disease and intestinal tuberculosis.
Not available
S-EPMC4796817 | biostudies-literature
TranscriptomicsModulation of colonic inflammation in Mdr1a-/- mice by green tea polyphenols and their effects on the colon transcriptome and proteome
This study tested the anti-inflammatory potential of a green tea extract rich in polyphenols (GrTP) in the colon of the multi-drug resistance targeted mutation (Mdr1a-/-) mouse model of IBD. A colonic histological injury score was determined for each mouse to establish the effect of GrTP on inflamma...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-41644 | biostudies-arrayexpress
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