Sort   by:  
 Page size 
ProteomicsCleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis severity and progression
The major proteoglycan in cartilage is COMP. This protein undergoes extensive proteolytic turnover that is believed to be dysregulated during osteoarthritis. Here we identify and describe two secreted proteases that are responsible for this turnover and identify the specific sites of proteolysis by ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-26 | PXD057263 | Pride
Comp Proteoglycan Osteoarthritis Adamts5 Adamts1 
TranscriptomicsCartilage Oligomeric Matrix Protein (COMP) contributes to the development and metastasis of breast cancer
Cartilage Oligomeric Matrix Protein (COMP) is a soluble pentameric protein expressed in cartilage and involved in collagen organization. Publicly available mRNA expression array data indicated that COMP is overexpressed in breast cancer tissue. Tissue microarrays derived from two cohorts of patients...
ORGANISM(S): Homo sapiens 
2015-10-01 | GSE69668 | GEO
UnknownDecreased Plasma COMP and Increased Plasma CTX-II Levels in a Chinese Pseudoachondroplasia Family with Novel COMP Mutation.
Not available
S-EPMC5591969 | biostudies-literature
TranscriptomicsExpression analysis of WT and COMP KO peritoneal macrophages elicited by thioglycollate
Investigation of whole genome gene expression level changes in COMP KO macrophages compared with WT macrophages.
ORGANISM(S): Mus musculus 
2015-10-14 | GSE73944 | GEO
UnknownCOMP-1 promotes competitive advantage of nematode sperm.
Not available
S-EPMC4400581 | biostudies-literature
UnknownMutations in COMP cause familial carpal tunnel syndrome.
Not available
S-EPMC7371736 | biostudies-literature
UnknownCOMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity.
Not available
S-EPMC5986769 | biostudies-literature
TranscriptomicsThe Cartilage Oligomeric Matrix Protein (COMP) Gene Is Associated with High-Grade Bladder Cancer and Promotes Bladder Cancer Cell Proliferation
Bladder cancer (BLCA) is a globally prevalent malignancy that poses a severe threat to patient health. Accurate high/low-grade classification of BLCA is critical for tailoring effective treatment strategies. This study integrated eight single-cell RNA sequencing (scRNA-seq) datasets and bulk RNA seq...
ORGANISM(S): Homo sapiens 
2025-11-28 | GSE311318 | GEO
UnknownA novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia.
Not available
S-EPMC3320758 | biostudies-literature
UnknownTwo novel mutations of COMP in Japanese boys with pseudoachondroplasia.
Not available
S-EPMC5993830 | biostudies-literature
Sort   by:  
 Page size