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TranscriptomicsRepeated systemic challenge with lipopolysaccharides induces dopaminergic neurodegeneration in the brain by activation of the complement-phagosome pathway
Systemic inflammatory reactions mediated by chronic infections activate microglia in the central nervous system (CNS) and have been postulated to exacerbate neurodegenerative diseases. We now demonstrate in vivo that repeated systemic challenge of mice with bacterial lipopolysaccharides (LPS) mainta...
ORGANISM(S): Mus musculus 
2014-07-11 | E-MTAB-1770 | biostudies-arrayexpress
MetabolomicsElectroacupuncture at Ll11 and SP10 is associated with alleviation of acute urticaria-like reactions in passive cutaneous anaphylaxis: an exploratory analysis of complement-related proteins and multiscale omics

Background: The lifetime prevalence of acute urticaria is approximately 20%. Although electroacupuncture (EA) has been investigated as an adjunctive treatment for urticaria, the molecular mechanisms underlying these effects remain elusive. Passive cutaneous anaphylaxis (PCA) serves as an experime...

2026-06-03 | MTBLS14327 | MetaboLights
ProteomicsComplement C3 deposition on nucleic acids is characteristic of immune complex initiated classical pathway overdrive in lupus erythematosus
Systemic lupus erythematosus is progressive, immune complex-mediated autoimmune disease targeting numerous organs. A central feature of the disease is the development of antibodies against nuclear components, including DNA. Antibodies against double-stranded DNA are so characteristic of this disease...
ORGANISM(S): Homo sapiens 
2012-09-30 | E-GEOD-26768 | biostudies-arrayexpress
ProteomicsGlycoproteomic and genetic analysis of N-glycosylation of complement component C3 reveals immune pathway regulation
This dataset comprises site-specific glycopeptide analysis of complement component C3 from plasma samples of 816 adults from the Korčula cohort (Croatia). C3 glycopeptides were enriched using Concanavalin A lectin affinity chromatography and analyzed by nano-LC-MS/MS. The study characterizes the N-g...
ORGANISM(S): Homo sapiens (Human) 
2026-05-30 | PXD074569 | Pride
Glycoproteomics Complement c3 High-mannose glycans N-glycosylation 
ProteomicsN-glycosylation analysis of human complement component C3 LC-MS - annotation data
The most abundant and central component, glycoprotein C3, contributes to the development of type 1 diabetes by enhancing the organ-specific autoimmune inflammatory processes. It is known that changes in glycosylation can modulate inflammatory responses and we recently showed that children at the ons...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035126 | Pride
Complement c3 
TranscriptomicsComplement Factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice.
Purpose: The complement system is closely linked to the pathogenesis of age-related macular degeneration (AMD). Several complement genes are expressed in retinal pigment epithelium (RPE), and complement proteins accumulate in drusen. Further, a common variant of complement factor H (CFH) confers inc...
ORGANISM(S): Mus musculus 
2012-10-02 | E-GEOD-38671 | biostudies-arrayexpress
ProteomicsQuantitative cross-linking/mass spectrometry analysis revealed unknown structure of complement iC3
We applied quantitative cross-linking/mass spectrometry (QCLMS) to interrogate the structure of iC3 (or C3(H2O)), the activated hydrolytic product of the abundant human complement protein C3. The slow but spontaneous and ubiquitous formation of iC3 from C3 initiates antibody-independent activation o...
ORGANISM(S): Homo sapiens (Human) 
2016-06-17 | PXD003486 | Pride
Quantitative cross-linking/mass spectrometry  domain architecture  activation of complement system  alternative pathway 
ProteomicsAngiotensinogen and C3 compete for renin-induced complement activation
Demonstration of renin cleavage of C3. Angiotensinogen and C3 compete for renin-induced complement activation.
ORGANISM(S): Homo sapiens (Human) 
2025-04-18 | PXD053116 | Pride
C3 Renin Angiotensinogen Lc-ms/ms 
ProteomicsN-glycosylation analysis of human complement component C3 LC-MS
The most abundant and central component, glycoprotein C3, contributes to the development of type 1 diabetes by enhancing the organ-specific autoimmune inflammatory processes. It is known that changes in glycosylation can modulate inflammatory responses and we recently showed that children at the ons...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD034083 | Pride
Lc-ms c3 
ProteomicsUrine complement analysis implies complement activation is involved in membranous nephropathy
Total 1,427 differentially expressed proteins were identified between the MN and HC groups. KEGG pathway analysis showed significant enrichment of these DEPs in the complement-activated pathway within the MN group. Additionally, a correlation was found between proteinuria and the levels of 27 urinar...
ORGANISM(S): Homo Sapiens 
2025-02-01 | PXD060494 |
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