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MetabolomicsOlive Oil Authenticity Studies by Target and Non-target LC-QTOF-MS combined with Advanced Chemometric Techniques
Food analysis is continuously requesting the development of more robust, efficient and cost-effective food authentication analytical methodologies to guarantee the safety, quality and traceability of food commodities with respect to legislation and consumer demands. Hence, a novel RP-UHPLC-ESI-QTOF-...
2017-05-04 | MTBLS433 | MetaboLights
ProteomicsVDAC2 ligands selectively and potently block BAK-mediated apoptosis to allow long-term clonogenic cell survival
This study aimed to characterise the protein that a novel compound binds to, thus promoting its ability to inhibit BAK apoptotic activity.
ORGANISM(S): Homo sapiens (Human) 
2019-10-11 | PXD013129 | Pride
Compound target id 
ProteomicsElenbecestat and compound 89 potently inhibit BACE1 but not BACE2 when subchronically dosed in non-human primates
The beta-secretase BACE1 (beta-site amyloid precursor (APP)-cleaving enzyme 1) is a major drug target for Alzheimer’s disease (AD), as it catalyzes the first step in amyloid beta (Abeta) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical tr...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-11-07 | PXD067413 | Pride
Proteomics Csf Bace1 inhibition Nhp Lc-ms/ms 
ProteomicsElenbecestat and compound 89 potently inhibit BACE1 but not BACE2 when subchronically dosed in non-human primates
The beta-secretase BACE1 (beta-site amyloid precursor (APP)-cleaving enzyme 1) is a major drug target for Alzheimer’s disease (AD), as it catalyzes the first step in amyloid beta (Abeta) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical tr...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-11-07 | PXD067461 | Pride
Proteomics Csf Bace1 inhibition Nhp Lc-ms/ms 
ProteomicsIdentification of Aryl Hydrocarbon Receptor (AhR) as a Functional Target that Enhances Astrocytic ApoE Secretion
We discovered a chemical series that enhances ApoE secretion from human astrocytes through mechanisms independent of LXR agonism. Using chemoproteomics, photoaffinity probes, KINOMEscan analysis, and siRNA knockdowns, we identified the aryl hydrocarbon receptor (AhR), a transcription factor not prev...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD071908 | Pride
Target id Lc-ms/ms 
UnknownId-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target.
Not available
S-EPMC3594064 | biostudies-literature
MetabolomicsMetabolomics reveals molecular signatures for psoriasis biomarkers and drug targets discovery
Psoriasis is a chronic skin disease that affects multiple systems and can be influenced by immunological, environmental, and genetic factors. The discovery of plasma biomarkers of psoriasis and the regulation of metabolic pathways helps us understand psoriasis and may assist clinicians in the diagno...
2024-09-26 | MTBLS5185 | MetaboLights
TranscriptomicsCUT&ID of 8 targets in HCT116
We developed CUT&ID, that simultaneously profiles genome-wide DNA and protein associations of any endogenous target in its native state, from one sample in a single streamlined workflow, and with no need of cloning or transgenesis. CUT&ID is enabled by a single fusion protein combining TurboID, prot...
ORGANISM(S): Homo sapiens 
2025-12-28 | E-MTAB-16382 | biostudies-arrayexpress
ProteomicsIndolin-2-one nitroimidazole antibiotics exhibit an unexpected dual mode of action
Nitroimidazoles such as metronidazole are used as anti-infective drugs against anaerobic bacteria. Upon in vivo reduction of the nitro group, reactive radicals damage DNA and proteins in the absence of oxygen. Unexpectedly, a recent study of nitroimidazoles linked to an indolin-2-one substituent rev...
ORGANISM(S): Staphylococcus aureus 
2022-11-09 | PXD033128 | Pride
Antibiotics Target-id Abpp 
ProteomicsA specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells
Elevated aldehyde dehydrogenase (ALDH) activity correlates with poor outcome for many solid tumors as ALDHs potentially regulate cell proliferation and chemoresistance of cancer stem cells (CSCs). Accordingly, potent and selective inhibitors of key ALDHs may represent a novel CSC-directed treatment ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028125 | Pride
Human Cancer Target-id Small molecule 
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