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ProteomicsStructural mechanism of a drug-binding process involving a large conformational change of the protein target
Structural biology studies indicate that proteins often undergo large conformational changes when binding small molecules, but atomic-level descriptions of binding events involving such changes have been elusive. A prominent example of binding accompanied by a large conformational change is the bind...
ORGANISM(S): Homo sapiens (Human) 
2023-04-07 | PXD034008 | Pride
Hdx ms Hydrogen exchange mass spectrometry Molecular dynamics simulations  drug binding  abl kinase  localized unfolding  imatinib resistance 
UnknownParsimony in Protein Conformational Change.
Not available
S-EPMC4497923 | biostudies-literature
UnknownConformational change in the chromatin remodelling protein MENT.
Not available
S-EPMC2648895 | biostudies-literature
ProteomicsAn isobaric quantitative crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and protein complexes
Experimental determination of protein conformational states is crucial to understand the mechanism of protein function and how function is altered in disease. We introduce a novel, simple and compact, isobaric crosslinker design for studying conformational and structural changes using quantitative m...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-11-13 | PXD035939 | Pride
Conformational change. Qclms Q2linkers Qlinker Isobaric 
UnknownCCProf: exploring conformational change profile of proteins.
Not available
S-EPMC4808249 | biostudies-literature
ProteomicsDynamics of integrin α5β1, fibronectin, and their complex
Integrin α5β1 mediates cell adhesion to the extracellular matrix (ECM) by binding fibronectin (Fn). Selectivity for Fn by α5β1 is achieved through recognition of an RGD motif in the 10th type-III Fn domain (Fn10) and the synergy site in the 9th type-III Fn domain (Fn9). However, details of the inter...
ORGANISM(S): Homo sapiens (Human) 
2022-08-09 | PXD031508 | Pride
Integrin Thermal stability Conformational change Hydrogen deuterium exchange Fibronectin Affinity 
UnknownCan conformational change be described by only a few normal modes?
Not available
S-EPMC1367309 | biostudies-literature
UnknownSolvation energetics and conformational change in EF-hand proteins.
Not available
S-EPMC2373930 | biostudies-literature
UnknownNew insights into the spring-loaded conformational change of influenza virus hemagglutinin.
Not available
S-EPMC155089 | biostudies-literature
UnknownManipulation of conformational change in proteins by single-residue perturbations.
Not available
S-EPMC2913187 | biostudies-literature
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