This study aimed to elucidate the metabolic process of IncX3 plasmid within conjugated strains, by utilizing untargeted LC-MS/MS profiling. In this study, the blaNDM-5-carrying IncX3 plasmid was successfully conjugated into Escherichia coli J53, which was confirmed to enhance both carbap...
Antimicrobial resistance (AMR) is one of the most urgent challenges in public health, and the horizontal transfer of antibiotic resistance genes (ARGs) mediated by mobile genetic elements (MGEs) drives its widespread global dissemination. Although integrative conjugative elements (ICEs) outnumber...