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ProteomicsBrain Proteomic Atlas of Alcohol Use Disorder in Adult Males
Alcohol use disorder (AUD) affects transcriptomic, epigenetic and proteomic expression in several organs including the brain. Multi-omic analyses of the brain from individuals with AUD to date lack a comprehensive analysis of protein alterations in the multiple brain regions that underlie neuroadapt...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040884 | Pride
Alcoholism Brain Proteomics Drug targets Alcohol use disorder 
ProteomicsProteomic Alterations Associated with Residual Disease in Neoadjuvant Chemotherapy Treated Ovarian Cancer Tissues
Optimal cytoreduction to no residual disease (R0) correlates with improved disease outcome in the management of high-grade serous ovarian cancer (HGSOC) patients. Neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) offers an alternate approach to management of HGSOC patients...
ORGANISM(S): Homo sapiens (Human) 
2022-10-05 | PXD031929 | Pride
Residual disease Mass spectrometry Precision medicine Neoadjuvant chemotherapy High-grade serous ovarian cancer Proteomics 
ProteomicsELMO1 signaling is a promoter of osteoclast function and bone loss
Osteoporosis and bone fractures affect millions of men and women worldwide and are often due to increased bone resorption (bone loss) mediated by osteoclasts. Here, we identify a novel role for the cytoplasmic protein ELMO1 as an important ‘signaling node’ controlling the bone resorption function of...
ORGANISM(S): Homo sapiens (Human) 
2021-06-07 | PXD023578 | Pride
Bone loss Osteoclasts Elmo1 Gelc-ms 
ProteomicsProteogenomic analysis of lung adenocarcinoma reveals tumor heterogeneity, survival determinants and therapeutically-relevant pathways
To characterize the etiology of lung adenocarcinoma (LUAD) in the United States, we performed deep proteogenomic profiling of 87 tumors integrating whole genome sequencing, transcriptome sequencing, proteomics and phosphoproteomics by mass spectrometry and reverse phase protein arrays. Somatic genom...
ORGANISM(S): Homo sapiens (Human) 
2022-11-16 | PXD036025 | Pride
Apollo Lung adenocarcinoma 
ProteomicsProteogenomic characterization of invasive breast tumors in young women
Breast cancer in women <40, accounting for ~5% of all breast cancer cases diagnosed in the U.S., is more aggressive and associated with worse outcomes compared to breast cancer in older women. We performed a first-ever integrated proteogenomic study from a matched cohort of laser-microdissected tumo...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD066224 | Pride
Laser microdissection Proteogenomics Breast cancer 
ProteomicsMolecular analysis of clinically defined subsets of high-grade serous ovarian cancer
The diversity and heterogeneity within high-grade serous ovarian cancer (HGSC) is not well understood. Comprehensive molecular analyses were performed including high-pass whole-genome sequencing, targeted deep DNA sequencing, RNA sequencing, reverse-phase protein arrays, mass spectrometry-based prot...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD014980 | Pride
Human Ovarian cancer Tissue 
UnknownErlotinib, erlotinib-sulindac versus placebo: a randomized, double-blind, placebo-controlled window trial in operable head and neck cancer.
Not available
S-EPMC4104657 | biostudies-literature
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