120065 Results

Show all   Save search   Copy query
Sort   by:  
 Page size 
Notch signaling regulates a variety of developmental cell fates decisions in a cell-context dependent manner. Although Notch signaling directly regulates transcription via the RBP-J/CSL DNA binding protein, little is known about the genes in the respective tissues that are directly activated by Notc...
ORGANISM(S): Mus musculus 
Specialized niche environments specify and maintain stem and progenitor cells, but little is known about the identities and functional interactions of niche components in vivo. Here, we describe a modular system for the generation of artificial hematopoietic niches in the mouse embryo. A circumscrib...
ORGANISM(S): Mus musculus 
DNA-binding anticancer agents cause alteration in chromatin structure and dynamics. Here, we report the dynamic interaction of the DNA intercalator and potential anticancer, plant alkaloid, sanguinarine (SGR) with chromatin. Association of SGR with different levels of chromatin structure was found t...
ORGANISM(S): Homo sapiens 
Protein degradation targets in hippocampus of the aged brain following context exposure
ORGANISM(S): Rattus norvegicus (Rat) 
2024-08-01 | PXD051644 | Pride
DNA binding anticancer agents cause alteration in chromatin structure and dynamics. Here, we report the dynamic interaction of the DNA intercalator and potential anticancer, plant alkaloid, Sanguinarine (SGR) with chromatin. Association of SGR with different levels of chromatin structure was found t...
ORGANISM(S): Homo sapiens 
The microRNA (miRNA) dependent regulation of gene expression confers robustness to cellular phenotypes and controls responses to extracellular stimuli. Although a single miRNA can regulate expression of hundreds of target genes, it is unclear whether any of its distinct biological functions can be d...
ORGANISM(S): Mus musculus 
This SuperSeries is composed of the following subset Series: GSE34857: Sequence-specific targeting of dosage compensation in Drosophila favors an active chromatin context (ChIP-chip) GSE34858: Sequence-specific targeting of dosage compensation in Drosophila favors an active chromatin context (mRNA) ...
ORGANISM(S): Drosophila melanogaster 
The stimulation of trimethylation of histone H3 lysine 4 (H3K4) by H2B monoubiquitination (H2Bub) has been widely studied with multiple mechanisms proposed for this form of histone crosstalk. Cps35/Swd2 within COMPASS is considered to bridge these processes. However, a truncated form of Set1 (762-Se...
ORGANISM(S): Saccharomyces cerevisiae 
Nucleosomes are barriers to transcription in vitro, however, their effects on RNA polymerase in vivo are unknown. Here we describe a simple and general strategy to comprehensively map the positions of elongating and arrested RNA Polymerase II (RNAPII) at nucleotide resolution. Our results suggest th...
ORGANISM(S): Drosophila melanogaster 
Exploitable, highly context-specific astrocytes
Sort   by:  
 Page size