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MetabolomicsSpatiotemporal determination of metabolite activities in the corneal epithelium on a chip
The corneal epithelial barrier maintains the metabolic activities of the ocular surface by regulating membrane transporters and metabolic enzymes responsible for the homeostasis of the eye as well as the pharmacokinetic behavior of drugs. Despite its importance, no established biomimetic in vitro me...
2021-07-13 | MTBLS2274 | MetaboLights
TranscriptomicsCorneal Gene Expression Analysis
Transplantation of amniotic membrane-expanded limbal epithelium (AMLE) in place of donor tissue grafts results in significantly improved outcomes for patients suffering from severe limbal stem cell deficiency; however the reasons for such superior results are unclear. The purpose of this study was t...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-56421 | biostudies-arrayexpress
GenomicsGenome-Wide Binding of Ehf in mouse corneal epithelium
The cornea, composed of epithelium, stroma and endothelium, protects the anterior compartment of the eye from damage and allows transmission of light into the eye. While well described morphologically, no studies have investigated the global gene expression changes in the cornea throughout the mous...
ORGANISM(S): Mus musculus 
2013-08-27 | E-GEOD-44741 | biostudies-arrayexpress
TranscriptomicsLimbal and Central Corneal Epithelia
Limbal and central regoins of the rat cornea epithelium were used to constract 2 SAGE libraries, in order to identify candidate genes to distinguish stem cell from differentiated central cornea epithelium cells. Keywords: gene expression SAGE-based, count cornea epithelium was scraped from central ...
ORGANISM(S): Rattus norvegicus 
2006-05-15 | E-GEOD-4121 | biostudies-arrayexpress
ProteomicsProteomics analysis of amyloid corneal aggregates from lattice corneal dystrophy patients
TGFBI associated Corneal Dystrophies (CD) are a group of inherited protein folding disorders linked to the mutation in the TGFBI gene. The resultant mutant protein (TGFBIp) is deposited as insoluble protein aggregates in various layers of the cornea leading to corneal opacity and poor vision. Depen...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD006640 | Pride
Corneal dystrophy Tgfbip Laser capture microdissection Amyloid fibrils Tgfbi Lattice corneal dystrophy Htra1 Apolipoprotein 
TranscriptomicsmicroRNA Expression of mice corneal endothelia
MicroRNA profile comparison of the corneal endothelium of young and old mice: implications for senescence of the corneal endothelium We collected the corneal endothelia from 30 mice aged 10-13 weeks and the corneal endothelia from 30 mice aged 2 years. The samples were pooled into six groups (y1, y2...
ORGANISM(S): Mus musculus 
2013-12-27 | E-GEOD-48094 | biostudies-arrayexpress
GenomicsscRNAseq of mouse corneal epithelium in homeostasis
scRNAseq of mouse corneal epithelium in homeostasis
PRJNA756967 | ENA
GenomicsscRNAseq of diabetic corneal epithelium
scRNAseq of diabetic corneal epithelium
PRJNA756322 | ENA
TranscriptomicsTranscriptomic analysis of cultured corneal endothelial cells as a validation for their use in cell-replacement therapy
The corneal endothelium plays a primary role in maintaining corneal homeostasis and clarity, and must be surgically replaced with allogenic donor corneal endothelium in the event of visually significant dysfunction. However, a worldwide shortage of donor corneal tissue has led to a search for altern...
ORGANISM(S): Homo sapiens 
2015-09-04 | E-GEOD-65991 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human post-mortem conjunctivae and corneal epithelia
Whole human conjunctivae and human corneas were obtained from the National Disease Research Interchange (NDRI, Philadelphia, PA) and processed between 48 - 72 hr of death. No donor details apart from age, sex and cause of death were released. Criteria for inclusion were donor ages between 25 - 65 ye...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-5543 | biostudies-arrayexpress
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