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ProteomicsProtein recruitment on chromatin in the presence or absence of Plk1
Polo-like kinase 1 (Plk1) is an important protein kinase for checkpoint recovery and adaptation in response to DNA damage and replication stress. However, although Plk1 is present in S phase, little is known about its localization and function during unperturbed DNA replication. Here we used a previ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2021-08-25 | PXD022572 | Pride
Xenopus laevis Chromass Lcmsms 
ProteomicsIdentification of Plk1 interacting proteins by XChIP-MS
Polo-like kinase 1 (Plk1) is an important protein kinase for checkpoint recovery and adaptation in response to DNA damage and replication stress. However, although Plk1 is present in S phase, little is known about its localization and function during unperturbed DNA replication. Using Xenopus laevis...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2021-08-25 | PXD022440 | Pride
Lc-msms Xenopus laevis 
ProteomicsTranslational activators and mitoribosomal isoforms cooperate to mediate mRNA-specific translation in Schizosaccharomyces pombe mitochondria
Mitochondrial mRNAs encode key subunits of the oxidative phosphorylation complexes that produce energy for the cell. In Saccharomyces cerevisiae, mitochondrial translation is under the control of translational activators, specific to each mRNA. In Schizosaccharomyces pombe, which more closely resemb...
ORGANISM(S): Schizosaccharomyces pombe 927 
2021-10-11 | PXD025400 | Pride
Lc-msms Immunoprecipitation 
ProteomicsDiversity in pervasive translation. A new translational landscape of yeast.
Pervasive translation is a widespread phenomenon that plays an important role in de novo gene birth; however, its underlying mechanisms remain unclear. Based on multiple Ribosome Profiling datasets, we investigated the translational landscape of coding and noncoding regions of yeast. Therefore, we d...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-09-04 | PXD040766 | Pride
Genome evolution Mass spectrometry Non-canonical translation signals De novo coding products Noncoding genome Pervasive translation 
TranscriptomicsIntracranial self-stimulation regulates gene expression in rat hippocampus
Transcriptional profiling of rat hippocampus 4.5h post intracranial self-stimulation (ICSS) show that this treatment, which improves learning and memory processes in a variety of paradigms of implicit and explicit memory, regulates gene expression of genes related to cAMP-mediated signaling and regu...
ORGANISM(S): Rattus norvegicus 
2013-09-03 | E-GEOD-42793 | biostudies-arrayexpress
ProteomicsDifferential impact of phosphate availability on primary and specialized metabolism of Streptomyces lividans and Streptomyces coelicolor.
In order to define the impact of phosphate (Pi) availability on cellular metabolism the project aimed to perform a comparative analysis of the proteomes of two Streptomyces strains with different abilities to produce antibiotics, S. coelicolor and S. lividans as well as of the pptA mutant of S. livi...
ORGANISM(S): Streptomyces coelicolor Streptomyces lividans TK24 
2022-02-04 | PXD029263 | Pride
Label-free protein quantification Antibiotics Proteomics Streptomyces Phosphate Respiratory chain Oxidative stress Central carbon metabolism 
TranscriptomicsAnalysis of the Cerebral Cortex and Hippocampus Transcriptome Reveals Unique Molecular Changes in the Ts1Cje Mouse Model of Down Syndrome
Down syndrome is characterized by a complex phenotype that includes developmental disabilities and congenital anomalies. The molecular origin of these abnormalities is poorly understood. The objective of this study is to analyze whole transcriptome changes in the cortex and hippocampus of the Ts1Cje...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-49635 | biostudies-arrayexpress
TranscriptomicsMicroarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer’s disease
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that threatens to reach epidemic proportions as our population ages. Although much research has examined molecular pathways associated with AD, relatively few studies have focused on critical early stages. Our prior microarray stud...
ORGANISM(S): Homo sapiens 
2011-07-31 | E-GEOD-28146 | biostudies-arrayexpress
TranscriptomicsAstrocyte-encoded positional cues maintain sensorimotor circuit integrity
Astrocytes, the most abundant cells in the central nervous system, promote synapse formation and help refine neural connectivity. Although they are allocated to spatially distinct regional domains during development, it is unknown whether region-restricted astrocytes are functionally heterogeneous. ...
ORGANISM(S): Mus musculus 
2014-05-02 | E-GEOD-55054 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal brain aging reveals sexually dimorphic gene expression
Gene expression profiles were assessed in the hippocampus (HC), entorhinal cortex (EC), superior frontal gyrus (SG), and postcentral gyrus (PCG) across the lifespan of 63 cognitively intact individuals from 20-99 years old. New perspectives on the global gene changes that are associated with brain ...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-11882 | biostudies-arrayexpress
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