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ProteomicsSUMOylation proteomic analysis of renal cortical collecting duct cells
We profiled SUMO1 and SUMO2 modified proteins in cortical collecting duct (mpkCCD) as a precursor to targeted approaches to assess SUMO function. SUMO levels in cells following heat shock and treatment with deSUMOylation inhibitors were assessed.
ORGANISM(S): Mus musculus (Mouse) 
2019-10-07 | PXD013346 | Pride
Collecting duct Renal Kidney Sumoylation 
ProteomicsQuantitative proteomic analysis of SUMOylation in renal cortical collecting duct cells after aldosterone stimulation
SILAC was employed to investigate the effect of aldosterone stimulation on SUMOylation of cortical collecting duct (mpkCCD) cells.
ORGANISM(S): Mus musculus (Mouse) 
2019-10-07 | PXD013363 | Pride
Collecting duct Quantitative Renal Silac Kidney Sumoylation 
ProteomicsSpectral library for targeted analysis of mouse kidney cortical collecting duct
We generated a spectral library of kidney cortical collecting ducts (CCD) using data-dependent proteomics acquisition.
ORGANISM(S): Mus musculus (Mouse) 
2020-12-21 | PXD018795 | Pride
Pendrin Mouse Ccd 
ProteomicsComparative proteomic analysis of kidney distal convoluted tubule and cortical collecting duct cells following long-term hormonal stimulation
The distal convoluted tubule (DCT) and the cortical collecting ducts (CCD) are portions of renal tubule that are partly responsible for maintaining the systemic concentrations of potassium, sodium, calcium and magnesium. Despite being structurally similar, DCT and CCD cells have different transport ...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-15 | PXD005454 | Pride
Distal convoluted tubule Mouse Hormone Kidney Cortical collecting duct Long-term 
TranscriptomicsTranscriptome of a mouse kidney cortical collecting duct cell line: effects of aldosterone and vasopressin
In this study, we analyzed the transcriptome of a highly differentiated mouse clonal CCD principal cell line (mpkCCD(cl4)) and the changes in the transcriptome induced by aldosterone and vasopressin. Serial analysis of gene expression (SAGE) was performed on untreated cells and on cells treated with...
ORGANISM(S): Mus musculus 
2003-09-24 | E-GEOD-678 | biostudies-arrayexpress
GenomicsA broad hypoxic response in a mouse cortical collecting duct 2 derived cell line
A broad hypoxic response in a mouse cortical collecting duct 2 derived cell line
PRJEB53226 | ENA
ProteomicsTargeted proteomics analysis of cortical collecting ducts with Pendrin knockout
We analyzed microdissected cortical collecting ducts of pendrin knockouts using a sensitive targeted proteomics approach proteomics approach.
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD018791 | Pride
Pendrin Kidney Ccd 
GenomicsSGK1 REGULATION BY miR-466g IN CORTICAL COLLECTING DUCT CELLS
To study the effects of aldosterone on miRNA in the kidney cortical collecting duct, polarized mpkCCDc14 cell were treated with aldosterone or vehicle. A putative target for miR-466g was identified, the effect of modulating miR-466g levels on SGK1 levels was examined
ORGANISM(S): Mus musculus synthetic construct 
2016-04-16 | GSE80319 | GEO
ProteomicsUntargeted proteomics analysis of cortical collecting ducts of pendrin knockout mice
We compared the proteome of isolated pendrin knockout mice using a data-dependent proteomics acquisition protocol.
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD018792 | Pride
Pendrin Kidney Cortical collecting duct 
ProteomicscAMP/PKA signaling phosphorylates LRBA in renal collecting duct
Vasopressin/cAMP/protein kinase A (PKA)/aquaporin-2 (AQP2) water channels signaling in the kidneys is a canonical pathway that determines AQP2 activity in response to body fluid balance. AQP2 phosphorylation by PKA increases water reabsorption from urine for the prevention of further water loss. We...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-23 | PXD033852 | Pride
Pka substrates Aqp2 Lrba Renal collecting duct 
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