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TranscriptomicsCervical carcinoma-associated fibroblasts are DNA diploid and do not show evidence for somatic genetic alterations
Cancer-associated fibroblasts (CAFs) have been recognized as important contributors to cancer development and progression. However, opposing evidence has been published whether CAFs, in addition to epigenetic, also undergo somatic genetic alterations and whether these changes contribute to carcinoge...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-GEOD-29143 | biostudies-arrayexpress
TranscriptomicsGenome Haploidisation with Chromosome 7 Retention in Oncocytic Follicular Thyroid Carcinoma
Recurrent non-medullary thyroid carcinoma (NMTC) is a rare disease. We initially characterized 27 recurrent NMTC: 13 papillary thyroid cancers (PTC), 10 oncocytic follicular carcinomas (FTC-OV), and 4 non-oncocytic follicular carcinomas (FTC). A validation cohort composed of benign and malignant (bo...
ORGANISM(S): Homo sapiens 
2012-08-29 | E-GEOD-31828 | biostudies-arrayexpress
ProteomicsC. difficile strain 630 flagellin C modifications
In proteomics, the study of post-translational modifications often relies on some type of enrichment strategy. Here, we show that an approach that is commonly used in phosphoproteomics (Immobilised Metal Affinity Chromatography (Fe3+-IMAC)) also enriches for peptides with a unique post-translational...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2022-04-04 | PXD029552 | Pride
C. difficile Phosphoproteomics Flagellin 
UnknownDistinct movement patterns generate stages of spider web building.
Not available
S-EPMC8612999 | biostudies-literature
ProteomicsIn-depth specificity profiling of Pro-Pro endopeptidases (PPEPs) using combinatorial synthetic peptide libraries
Proteases comprise the class of enzymes that catalyze the hydrolysis of peptide bonds, thereby playing a pivotal role in many aspects of life. The amino acids surrounding the scissile bond determine the susceptibility towards protease-mediated hydrolysis. A detailed understanding of the cleavage spe...
ORGANISM(S): Paenibacillus alvei DSM 29 Geobacillus stearothermophilus Clostridioides difficile 
2023-08-01 | PXD038277 | Pride
Pro-pro endopeptidase Specificity profiling Mass spectrometry (ms) Ppep Synthetic peptide libraries Substrate specificity High-performance liquid chromatography (hplc) Fret peptides Metalloprotease 
UnknownPhylogenetic analysis of the bacterial Pro-Pro-endopeptidase domain reveals a diverse family including secreted and membrane anchored proteins.
Not available
S-EPMC8610288 | biostudies-literature
UnknownRedefining the Clostridioides difficile σB Regulon: σB Activates Genes Involved in Detoxifying Radicals That Can Result from the Exposure to Antimicrobials and Hydrogen Peroxide.
Not available
S-EPMC7494833 | biostudies-literature
UnknownClostridium difficile TcdC protein binds four-stranded G-quadruplex structures.
Not available
S-EPMC3575817 | biostudies-literature
UnknownA Bioluminescent Sensor for Rapid Detection of PPEP-1, a Clostridioides difficile Biomarker.
Not available
S-EPMC8624784 | biostudies-literature
UnknownCharacterization of the Clostridioides difficile 630Δerm putative Pro-Pro endopeptidase CD1597.
Not available
S-EPMC11460543 | biostudies-literature
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