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ProteomicsProteomics of diphtheria toxoid vaccines reveals multiple proteins that are immunogenic and may contribute to protection of humans against Corynebacterium diphtheriae
Introduced for mass immunization in the 1920s, vaccines against diphtheria are among the oldest and safest vaccines known. The basic principle of their production is the inactivation of purified diphtheria toxin by formaldehyde cross-linking, which converts the potentially fatal toxin in a completel...
ORGANISM(S): Corynebacterium diphtheriae NCTC 13129 Clostridium tetani E88 
2019-04-18 | PXD012806 | Pride
Proteomics Mass spectrometry Coryebacteria Exoproteome Vaccination Secretome 
ProteomicsMonitoring global protein thiol-oxidation and protein S-mycothiolation in Corynebacterium diphtheriae under hypochlorite stress
Mycothiol (AcCys-GlcN-Ins, MSH) is the major thiol-redox buffer in Actinomycetes, including Mycobacterium and Corynebacterium species. Protein S-mycothiolation controls the activities of several redox enzymes that function in detoxification of ROS and methionine sulfoxides, including the thiol perox...
ORGANISM(S): Corynebacterium diphtheriae 
2017-07-17 | PXD003321 | Pride
Oxicat Corynebacterium diphtheria S-mycothiolation Bacteria Oxidative stress Mycothiol 
ProteomicsHelpful dirt: Why diphtheria toxoid vaccines may also protect against non-toxigenic Corynebacterium diphtheriae strains
Diphtheria toxoid vaccines are among the oldest and safest vaccines known. The basic principle of production is the inactivation of purified diphtheria toxin by formaldehyde cross-linking, which converts the potentially fatal toxin in a completely harmless protein aggregate, which is still immunogen...
ORGANISM(S): Corynebacterium diphtheriae NCTC 13129 Clostridium tetani E88 
2019-04-17 | PXD009289 | Pride
Proteomics Corynebacterium ulcerans Mass spectrometry Corynebacteria Exoproteome Vaccination Secretome 
TranscriptomicsIpsA, a novel transcriptional regulator required for inositol derived lipid formation in Corynebacteria and Mycobacteria
The development of new drugs against tuberculosis and diphtheria is focused on disrupting the biogenesis of the cell wall, the unique architecture of which confers resistance against current therapies. The enzymatic pathways involved in the synthesis of the cell wall by these pathogens are well unde...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2014-01-13 | E-GEOD-50210 | biostudies-arrayexpress
UnknownDetection of differences in the nucleotide and amino acid sequences of diphtheria toxin from Corynebacterium diphtheriae and Corynebacterium ulcerans causing extrapharyngeal infections.
Not available
S-EPMC254330 | biostudies-literature
UnknownDetection and Characterization of Diphtheria Toxin Gene-Bearing Corynebacterium Species through a New Real-Time PCR Assay.
Not available
S-EPMC7512153 | biostudies-literature
UnknownWhole genome sequencing suggests transmission of Corynebacterium diphtheriae-caused cutaneous diphtheria in two siblings, Germany, 2018.
Not available
S-EPMC6337054 | biostudies-literature
GenomicsCorynebacterium diphtheriae strain:BQ11
Fatal respiratory diphtheria caused by Beta-lactam-resistant toxigenic Corynebacterium diphtheriae
PRJNA473263 | ENA
UnknownRapid detection and molecular differentiation of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by LightCycler PCR.
Not available
S-EPMC3147892 | biostudies-literature
ProteomicsCorynebacterium diphtheriae proteome adaptation to cell culture medium and serum
ost-pathogen interactions are often studied in vitro using primary or immortal cell lines. This set-up avoids ethical problems of animal testing and has the additional advantage of lower costs. However, the influence of cell culture media on bacterial growth and metabolism is not considered or inves...
ORGANISM(S): Corynebacterium diphtheriae bv. mitis str. ISS 3319 
2021-03-12 | PXD024381 | Pride
Metabolic pathway Proteomics Host-pathogen interaction Label-free Diphtheria 
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