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ProteomicsMass Spectrometry-Driven Epitope Mapping: Application of Diethylpyrocarbonate Covalent Labeling for the Immunotherapeutic Target Programmed Cell Death Protein 1
Monoclonal antibodies (mAbs) have transformed cancer immunotherapy, with anti-PD1 mAbs playing a pivotal role. This study introduces diethylpyrocarbonate covalent labeling-mass spectrometry (DEPC CL-MS) as a rapid and sensitive technique for epitope mapping of PD1, a critical target in mAb developme...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-26 | MSV000096536 | MassIVE
ProteomicsHigh-Throughput Screening of Amyloid Inhibitors via Covalent-Labeling Mass Spectrometry
MS spectra of DEPC modifications on beta-2-microglobulin (b2m) residues under amyloid-forming conditions, with or without 4-hydroxythalidomide.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-06-25 | MSV000098322 | MassIVE
ProteomicsStrategies for Acid and Amine Cross-linking and Labeling for Protein Structural Characterization Using Mass Spectrometry
Raw data from the manuscript "Strategies for Acid and Amine Cross-linking and Labeling for Protein Structural Characterization Using Mass Spectrometry" in Analytical Chemistry 2025 vol 97 issue 15
ORGANISM(S): Homo Sapiens (human) 
2025-05-15 | PXD063980 | JPOST Repository
TranscriptomicsIn vivo proximity labeling and sequencing (IPL-seq) for SNRPN70 in 293T-Rex
This proof-of-principle experiment was designed to demonstrate the feasibility of proximity labeling for RNAM-bM-^@M-^Sprotein interactions IPL-seq on 293T-Rex expressing MSA-SNRPN70 (sample) or NFH-SNRPN70 (control)
ORGANISM(S): Homo sapiens 
2014-10-24 | E-GEOD-55370 | biostudies-arrayexpress
UnknownProtein labeling and crosslinking by covalent aptamers.
Not available
S-EPMC10725707 | biostudies-literature
ProteomicsTunable activated esters for lysine labeling in proteome
The development of various heteroaromatic activated esters designed for selective lysine labeling within the proteome for profiling purposes. Through systematic optimization of the reactivity and selectivity of these esters, we identified a series of effective probe molecules suitable for both in vi...
ORGANISM(S): Homo Sapiens 
PXD051323 |
UnknownBiocompatible sulfonium-based covalent probes for endogenous tubulin fluorescence nanoscopy in live and fixed cells.
Not available
S-EPMC12701065 | biostudies-literature
UnknownUtility of Covalent Labeling Mass Spectrometry Data in Protein Structure Prediction with Rosetta.
Not available
S-EPMC6520167 | biostudies-literature
UnknownCovalent Labeling Automated Data Analysis Platform for High Throughput in R (coADAPTr): A Proteome-Wide Data Analysis Platform for Covalent Labeling Experiments.
Not available
S-EPMC11622367 | biostudies-literature
UnknownProteins Can Withstand More Extensive Labeling while Providing Accurate Structural Information in Covalent Labeling-Mass Spectrometry.
Not available
S-EPMC11167616 | biostudies-literature
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