Sort   by:  
 Page size 
GenomicsCovalent PARylation of DNA base excision repair proteins regulates DNA demethylation
Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation
PRJNA702477 | ENA
ProteomicsCovalent histone modification by an electrophilic derivative of the anti-HIV drug nevirapine
Nevirapine (NVP), a non-nucleoside reverse transcriptase inhibitor widely used in combined antiretroviral therapy and to prevent mother-to-child transmission of the human immunodefi-ciency virus type 1, is associated with several adverse side effects. Using 12-mesyloxy-nevirapine, a model electroph...
ORGANISM(S): Homo sapiens (Human) 
2021-03-08 | PXD023751 | Pride
Covalent histone modification  mass spectrometry  drug-induced adverse reactions  covalent protein adducts  nevirapine 
UnknownCovalent Modification of Bromodomain Proteins by Peptides Containing a DNA Damage-Induced, Histone Post-Translational Modification.
Not available
S-EPMC9675715 | biostudies-literature
ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047141 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047137 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047138 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
ProteomicsPosttranslational modification analysis of Histone H3t
Comprehensive posttranslational modifications in the testis-specific histone variant H3t protein validated in tagged knock-in mice.
ORGANISM(S): Mus Musculus (mouse) 
2024-09-13 | PXD052428 | JPOST Repository
OtherCovalent PARylation of DNA base excision repair proteins regulates DNA demethylation
Poly(ADP-ribose) polymerases (PARP1 and PARP2) contribute to DNA base excision repair (BER) and DNA demethylation and has been implicated in epigenetic programming in early mammalian development. Recently, proteomic analyses identified BER proteins to be covalently poly-ADP-ribosylated by PARPs. The...
ORGANISM(S): Mus musculus 
2023-11-08 | GSE166963 | GEO
TranscriptomicsTranscription profiling by array of adenylylation of mycobacterial Glnk (PII) protein induced by nitrogen limitation
PII proteins are pivotal regulators of nitrogen metabolism in most prokaryotes, controlling the activities of many targets, including nitrogen assimilation enzymes, two component regulatory systems and ammonium transport proteins. Escherichia coli contains two PII-like proteins, PII (product of glnB...
ORGANISM(S): Mycobacterium tuberculosis 
2013-05-10 | E-BUGS-135 | biostudies-arrayexpress
ProteomicsNeissLock: an inducible protein anhydride for covalent targeting of endogenous proteins
Effective and convenient covalent protein conjugation could benefit diverse biological systems, stabilizing key protein protein interactions which are otherwise reversible. Neisseria meningitidis contains a protein which undergoes autoproteolysis via an anhydride. Here, we harness this spontaneously...
ORGANISM(S): Escherichia coli 
2021-02-01 | PXD023073 | Pride
Protein engineering Proximity labeling Chemical biology Synthetic biology Nanoassembly Protein conjugation 
Sort   by:  
 Page size