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ProteomicsExploiting the DCAF16-SPIN4 interaction to identify DCAF16 ligands for PROTAC development
Traditional small molecule drugs often target protein activity directly, but challenges arise when proteins lack suitable functional sites. An alternative approach is targeted protein degradation (TPD), which directs proteins to cellular machinery for proteolytic degradation. Recent studies have ide...
ORGANISM(S): Homo sapiens (Human) 
2024-12-06 | PXD055063 | Pride
Htrf Dcaf16 Protac 
UnknownExploiting the DCAF16-SPIN4 interaction to identify DCAF16 ligands for PROTAC development.
Not available
S-EPMC11647575 | biostudies-literature
UnknownDiscovery of DCAF16 Binders for Targeted Protein Degradation.
Not available
S-EPMC11973735 | biostudies-literature
UnknownSPIN4 Is a Principal Endogenous Substrate of the E3 Ubiquitin Ligase DCAF16.
Not available
S-EPMC8325951 | biostudies-literature
UnknownExploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues.
Not available
S-EPMC11960843 | biostudies-literature
UnknownTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders.
Not available
S-EPMC9949066 | biostudies-literature
UnknownElectrophilic PROTACs that degrade nuclear proteins by engaging DCAF16.
Not available
S-EPMC6592777 | biostudies-literature
ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047138 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047141 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047137 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
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