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ProteomicsRegulation of mitochondrial oxidative phosphorylation and venetoclax efficacy in AML via COX4I1
Cell signaling pathways are enriched for biological processes crucial for cellular communication, response to external stimuli, and metabolism. Here, we conducted a cell signaling-focused CRISPR screen and identified cytochrome c oxidase subunit 4I1 (COX4I1) as a novel vulnerability in acute myeloid...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050739 | Pride
Leukemia Cox4i1 Mitochondria 
GenomicsRNA-seq in human Molm13 cells with CRISPR knockout of COX4I1
RNA-seq in human Molm13 cells with CRISPR knockout of COX4I1
PRJNA1089648 | ENA
TranscriptomicsRNA-seq in human Molm13 cells with CRISPR knockout of COX4I1
This dataset examined the effect of COX4I1 knockout in the gene expression profiling (RNA-seq) of human Molm13 cells.
ORGANISM(S): Homo sapiens 
2025-02-19 | GSE261970 | GEO
UnknownNuclear Control of Mitochondrial Homeostasis and Venetoclax Efficacy in AML via COX4I1.
Not available
S-EPMC11809339 | biostudies-literature
ProteomicsLoss of COX4i1 leads to combined respiratory chain deficiency and impaired mitochondrial protein synthesis
The oxidative phosphorylation (OXPHOS) system localized in the inner mitochondrial membrane secures production of the majority of ATP in mammalian organisms. Individual OXPHOS complexes form supramolecular assemblies termed supercomplexes. The complexes are linked not only by their function but also...
ORGANISM(S): Homo sapiens (Human) 
2021-02-18 | PXD023367 | Pride
Knock-out Cox Mitochondria Oxphos Complex i Cox assembly Mitochondrial protein synthesis Cox4 Biogenesis interdependency Complexome profiling 
UnknownMutation in the COX4I1 gene is associated with short stature, poor weight gain and increased chromosomal breaks, simulating Fanconi anemia.
Not available
S-EPMC5602013 | biostudies-literature
ProteomicsThe Dynll1-Cox4il Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species
Cellular membrane proteins are a critical part of the host defense mechanisms against infection and intracellular survival of Listeria monocytogenes. The complex spatiotemporal regulation of bacterial infection by various membrane proteins has been challenging to study. Here, using mass spectrometry...
ORGANISM(S): Mus Musculus 
2020-02-17 | PXD016452 |
UnknownLoss of COX4I1 Leads to Combined Respiratory Chain Deficiency and Impaired Mitochondrial Protein Synthesis.
Not available
S-EPMC7916595 | biostudies-literature
Genomics
Research on the Role of Monocyte Abnormalities Caused by COX4I1 in the Mechanism of Clonal Evolution of Aplastic Anemia
PRJNA1499989 | ENA
UnknownScaling of smaller pyramidal neuron size and lower energy production in schizophrenia.
Not available
S-EPMC10898364 | biostudies-literature
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