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ProteomicsThe CDK12-inhibitor CR8 mediates Cyclin K degradation through the CUL4-RBX1-DDB1 E3 ubiquitin ligase
Small molecules have been identified that induce protein-protein interactions between a substrate and a ubiquitin ligase, resulting in targeted protein degradation. Such molecular glue compounds, unlike traditional enzyme inhibitors, act sub-stoichiometrically to catalyse rapid depletion of previous...
ORGANISM(S): Homo sapiens (Human) 
2020-06-10 | PXD016188 | Pride
Cr8 Cyclin k Molecular glue Cdk12 Ubiquitin Crl4ddb1 
ProteomicsThe CDK12-inhibitor CR8 mediates Cyclin K degradation through the CUL4-RBX1-DDB1 E3 ubiquitin ligase
Small molecules have been identified that induce protein-protein interactions between a substrate and a ubiquitin ligase, resulting in targeted protein degradation. Such molecular glue compounds, unlike traditional enzyme inhibitors, act sub-stoichiometrically to catalyse rapid depletion of previous...
ORGANISM(S): Homo sapiens (Human) 
2020-06-10 | PXD016187 | Pride
Crl4 Cr8 Cyclin k Molecular glue Cdk12 Ubiquitin Ddb1 
UnknownCR8, a selective and potent CDK inhibitor, provides neuroprotection in experimental traumatic brain injury.
Not available
S-EPMC3324621 | biostudies-literature
UnknownCDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells.
Not available
S-EPMC3092200 | biostudies-literature
UnknownCDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.
Not available
S-EPMC4087096 | biostudies-literature
UnknownSystemic Administration of the Cyclin-Dependent Kinase Inhibitor (S)-CR8 Selectively Reduces Escalated Ethanol Intake in Dependent Rats.
Not available
S-EPMC6779498 | biostudies-literature
UnknownStudies of a Large Odd-Numbered Odd-Electron Metal Ring: Inelastic Neutron Scattering and Muon Spin Relaxation Spectroscopy of Cr8 Mn.
Not available
S-EPMC4744977 | biostudies-literature
UnknownThe CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
Not available
S-EPMC7486275 | biostudies-literature
TranscriptomicsMicroarray analysis of BHLHB2 and BHLHB3 target genes in human skeletal muscle cells
In this study we have identified the target genes of BHLHB2 and BHLHB3 in primary cultures of human skeletal muscle cells using adenoviral vectors expressing either BHLHB2 or BHLHB3, and oligonucleotide microarrays. Human myotubes were prepared from 4 different skeletal muscle biopsies. After 7 day...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-12947 | biostudies-arrayexpress
UnknownComplete Genome Sequences of Two Citrobacter rodentium Bacteriophages, CR8 and CR44b.
Not available
S-EPMC4038870 | biostudies-literature
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