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GenomicsGenome-wide CRISPR-Cas9 knockout screen in MCF10A with ATP-competitive inhibition of CDC7 (XL-413)
The coordinated activation of DNA replication origins is important for efficient DNA synthesis and genome stability. S-phase cyclin dependent kinases (CDKs) together with CDC7 kinase, are essential to origin activation by converting the pre-replicative complex into a fully active helicase. To identi...
ORGANISM(S): Homo sapiens 
2026-09-30 | E-MTAB-17434 | biostudies-arrayexpress
ProteomicsMetabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen
Cancer cells depend on mitochondria to sustain their increased metabolic needs therefore, mitochondria constitute an interesting target for cancer treatment. We recently developed novel small-molecule inhibitors of mitochondrial transcription (IMTs) that selectively target mitochondrial gene express...
ORGANISM(S): Homo sapiens (Human) 
2021-11-11 | PXD026481 | Pride
Mtdna Cancer Crispr-cas9 genetic screen Inhibitor of mitochondrial transcription Chemoresistance 
TranscriptomicsGenome-wide CRISPR-Cas9 screen identifies protein-coding genes and microRNAs important in FLT3-ITD+ AML (MV4-11) cellular growth
The functional relevance of many microRNAs in the context of tumor biology remains unclear. Using CRISPR-Cas9 technology, we performed a global loss-of-function screen to test the impact of individual microRNAs on the growth of FLT3-ITD positive leukemia cells. This approach identified both evolutio...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-71539 | biostudies-arrayexpress
GenomicsIn vivo CRISPR/Cas9 screen to identify candidate therapeutic gene targets to enhance docetaxel efficacy in prostate cancer
Docetaxel chemotherapy in metastatic prostate cancer offers only a modest survival benefit due to emerging resistance. To identify candidate therapeutic gene targets, we applied a murine prostate cancer orthograft model that recapitulates clinical invasive prostate cancer in a genome-wide CRISPR/Cas...
ORGANISM(S): Mus musculus 
2020-10-07 | E-MTAB-9482 | biostudies-arrayexpress
TranscriptomicsGenome-wide CRISPR-Cas9 screens reveal loss of redundancy between PKMYT1 and WEE1 in Glioblastoma stem-like cells
To identify new therapeutic targets for Glioblastoma (GBM), we performed genome-wide CRISPR-Cas9 "knockout" (KO) screens in patient-derived GBM stem-like cells (GSCs) and human neural stem/progenitors (NSCs), non-neoplastic stem cell controls, for genes required for their in vitro growth. ...
ORGANISM(S): Homo sapiens 
2016-02-15 | E-GEOD-70038 | biostudies-arrayexpress
ProteomicsCRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neurodegeneration
Accumulation of aggregated and misfolded proteins, leading to endoplasmic reticulum stress and activation of the unfolded protein response, is a hallmark of several neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. Genetic screens are powerful tools that are proving invalua...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD038395 | Pride
Cortical neurons Kat2b L-moses Endoplasmic reticulum (er) stress Acetylome 
GenomicsSMYD5 is a regulator of the mild hypothermia response [CRISPR-Cas9 screen]
SMYD5 is a regulator of the mild hypothermia response [CRISPR-Cas9 screen]
PRJNA982781 | ENA
GenomicsIdentification of novel genetic interactions with Recql4 in a genome-wide CRISPR/Cas9 rescue screen.
Identification of novel genetic interactions with Recql4 in a genome-wide CRISPR/Cas9 rescue screen.
PRJNA1140548 | ENA
TranscriptomicsA secondary, tailored CRISPR-Cas9 knockout library targeting the specified genes was identified through the TP53 knockout genome-wide screen
A secondary custom CRISPR-Cas9 screen, encompassing the 132 genes identified in the genome-wide TP53 knockout screen along with additional 93 genes serving as positive and negative controls.
ORGANISM(S): Homo sapiens 
2025-12-13 | E-MTAB-13685 | biostudies-arrayexpress
GenomicsGenome-wide CRISPR-Cas9 screen to identify genes involved in radiotherapy response
Genome-wide CRISPR-Cas9 screen to identify genes involved in radiotherapy response
PRJEB103027 | ENA
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