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GenomicsGenome-wide mapping of Nup98HoxA9- and Crm1-binding sites in ES cell lines.
We used ChIP-seq to examine the genome-wide binding of Nup98-HoxA9 and Crm1 in ES cells. Our analysis revealed that Nup98-HoxA9 is highly and preferentially targeted to specific chromatin sites, particularly near Hox cluster regions where the export factor Crm1 is originally prebound. chromatin immu...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-68783 | biostudies-arrayexpress
ProteomicsExportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore
Non-centrosomal microtubule organizing centers (MTOCs) are important for microtubule organization in many cell types. In fission yeast Schizosaccharomyces pombe, the protein Mto1, together with partner protein Mto2 (Mto1/2 complex), recruits the g-tubulin complex to multiple non-centrosomal MTOCs, i...
ORGANISM(S): Schizosaccharomyces pombe 
2018-05-22 | PXD008334 | Pride
Crm1 Nuclear envelope Mtocs Schizosaccharomyces pombe Microtubules Mto2 Mto1 Nup146 
ProteomicsCRM1 Exportome and nucleocytoplasmic partition
CRM1 mediates one of the major nuclear export pathways with the broadest range of cargoes. So far, more than 100 structurally and functionally diverse CRM1 cargoes have been described. We employed affinity purification mass spectrometry for in depth characterization of CRM1 "exportome" in three mode...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) Xenopus laevis (African clawed frog) 
2016-01-04 | PXD002899 | Pride
Human Xenopus S.cerevisiae 
GenomicsChEC-seq2 profiling of Crm1 and Nup2 during degradation of Nup2 or inhibition/degradation of Crm1, respectively
Nuclear pore proteins (Nups) physically interact with hundreds of chromosomal sites, impacting transcription. In yeast, transcription factors mediate interactions between Nups and enhancers and promoters. To define the molecular basis of this mechanism, we exploited a separation-of-function mutation...
ORGANISM(S): Saccharomyces cerevisiae 
2025-03-24 | GSE288549 | GEO
ProteomicsInteractome analysis of Nup214 and CRM1
RIME/ChIP-MS analysis for Nucleoporin, Nup214 and CRM1. Rapid Immunoprecipitation Mass spectrometry of Endogenous proteins was used.
ORGANISM(S): Homo Sapiens (human) 
2023-07-26 | PXD042027 | JPOST Repository
ProteomicsCancer-associated mutations impair the capability of CRM1 to regulate NPAT condensation and histone locus body
Importins could inhibit the condensation of RNA-binding proteins, while it is proposed that exportins could not elicit a similar function. Here, we identified exportin CRM1 binds nuclear protein NPAT, which initiates and maintains the formation of histone locus body (HLB), a membrane-less nuclear bo...
ORGANISM(S): Homo Sapiens 
2024-12-08 | PXD058681 |
GenomicsChEC-seq2 profiling of yeast Gcn4 and Crm1-T539C localization after treatment with Leptomycin B.
Nuclear pore proteins (Nups) physically interact with hundreds of chromosomal sites, impacting transcription. In yeast, transcription factors mediate interactions between Nups and enhancers and promoters. To define the molecular basis of this mechanism, we exploited a separation-of-function mutation...
ORGANISM(S): Saccharomyces cerevisiae 
2025-03-24 | GSE288550 | GEO
GenomicsIL-6 Evades KSHV-Mediated Hyperadenylation repression via CRM1-Dependent Nuclear Export.
IL-6 Evades KSHV-Mediated Hyperadenylation repression via CRM1-Dependent Nuclear Export.
PRJNA1269618 | ENA
GenomicsChEC-seq2 profiling of Crm1, Nucleoporins (nups), and RNA Pol II from budding yeast grown in SDC
Nuclear pore proteins (Nups) physically interact with hundreds of chromosomal sites, impacting transcription. In yeast, transcription factors mediate interactions between Nups and enhancers and promoters. To define the molecular basis of this mechanism, we exploited a separation-of-function mutation...
ORGANISM(S): Saccharomyces cerevisiae 
2025-03-24 | GSE288515 | GEO
Otherthiol(SH)-linked alkylation for the metabolic sequencing (SLAM-seq) of RNA after Crm1 inhibition and Nup1/Nup2 degradation
Nuclear pore proteins (Nups) physically interact with hundreds of chromosomal sites, impacting transcription. In yeast, transcription factors mediate interactions between Nups and enhancers and promoters. To define the molecular basis of this mechanism, we exploited a separation-of-function mutation...
ORGANISM(S): Saccharomyces cerevisiae 
2025-03-24 | GSE288633 | GEO
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