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ProteomicsDeciphering Diazirine Reaction Mechanism: through Irradiation Modulation for Residue-Specific Distance Restraints in Protein Photo-Crosslinking
The diazirine photoreactive group has been widely used for photo-labeling and photo-cross-linking (PXL) of proteins. Yet, due to the mechanistic complexity of diazirine photo-reaction, site-specific and quantitative analysis of protein PXL data remains challenging. Herein, we have built an in-line p...
ORGANISM(S): Bos taurus (Bovine) 
2024-06-22 | PXD048452 | Pride
Photo cross-linking Multiple reaction monitoring Optical power density Distance restraints Alkyl diazirine 
ProteomicsOn the reproducibility of label-free quantitative cross-linking/mass spectrometry
Quantitative cross-linking/mass spectrometry (QCLMS) is an emerging approach to study conformational changes of proteins and multi-subunit complexes. Distinguishing protein conformations requires reproducibly identifying and quantifying cross-linked peptides. Here we analyzed the variation between m...
ORGANISM(S): Homo sapiens (Human) 
2018-01-02 | PXD007250 | Pride
Cross-linking Mass-spectrometry Skyline Quatitation 
UnknownNickel-catalyzed migratory alkyl-alkyl cross-coupling reaction.
Not available
S-EPMC8162388 | biostudies-literature
UnknownCross-Linking of Polypropylene via the Diels-Alder Reaction.
Not available
S-EPMC8955959 | biostudies-literature
ProteomicsSignal Attrition in Whole Cell Crosslinking Mass Spectrometry
We investigated points in the typical sample workflow that could contribute to the perceived low cross-linking yields. We demonstrate, through a 2-step cross-linking strategy called Click-Linking, that the chemical reaction is not the main contributor to the low number of identified cross-links. We ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-18 | PXD069512 | Pride
Cross-linking Xl-ms Reaction yield 
UnknownSynthesis of C4-alkynylisoxazoles via a Pd-catalyzed Sonogashira cross-coupling reaction.
Not available
S-EPMC9061866 | biostudies-literature
UnknownNickel-Catalyzed Suzuki-Miyaura Cross-Coupling Reaction of Aliphatic Alcohol Derivatives.
Not available
S-EPMC12304806 | biostudies-literature
UnknownCopper-catalyzed cross coupling reaction of sulfonyl hydrazides with 3-aminoindazoles.
Not available
S-EPMC9594103 | biostudies-literature
UnknownCathodic Aromatic C,C Cross-Coupling Reaction via Single Electron Transfer Pathway.
Not available
S-EPMC6155275 | biostudies-literature
ProteomicsDevelopment of Electrostatic-to-Covalent Gas Phase Cross-linkers for Protein Structure Measurements by Mass Spectrometry
The benefits of native mass spectrometry have led to the extensive study of proteins inside mass spectrometers in the gas phase. The expansion of native mass spectrometry requires novel tools for gaining greater insights into protein structures. Herein, we introduce a new approach utilizing gas phas...
ORGANISM(S): Homo Sapiens (human) Equus Caballus 
2026-01-20 | PXD073276 | JPOST Repository
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