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344 rats were treated twice, one week apart, with subcutaneous injections of 1,2-dimethylhydrazine (150 mg/kg x 2). Thirty-two weeks after the first DMH injection, rats were sacrificed and colonic tumours (T) and normal colon mucosa (NM) harvested and stored in RNAlater. Genomic DNA was extracted f...
ORGANISM(S): Rattus norvegicus 
Water is one of the resources most affected by the intensification of human activities. As consequences of these activities, we have eutrophication and global warming, which can also favor the blooms of cyanobacteria that produce cyanotoxins. Here we present the hepatic proteome of females and males...
ORGANISM(S): Rhamdia quelen 
2024-05-22 | PXD046475 | Pride
Gene expression in eukaryotes is an essential process that includes transcription, pre-RNA processing and RNA export. All these steps are coupled and normally, any failure in one step affects the other steps and could cause nuclear mRNA retention. One important player in this interface is the poly(A...
ORGANISM(S): Saccharomyces cerevisiae 
We performed a label free mass spectrometry-based proteomic analysis to investigate the effects of PCYOX1 silencing on the secretome of human HepG2 cells
ORGANISM(S): Homo sapiens (Human) 
2021-10-12 | PXD022302 | Pride
Gene expression in eukaryotes is an essential process that includes transcription, pre-RNA processing and RNA export. All these steps are coupled and normally, any failure in one step affects the other steps and could cause nuclear mRNA retention. One important player in this interface is the poly(A...
ORGANISM(S): Saccharomyces cerevisiae 
The epidermal specific ablation of Trp53 gene leads to the spontaneous development of aggressive tumors in mice through a process that is accelerated by the simultaneous ablation of Rb gene. Since alterations of p53-dependent pathway are common hallmarks of aggressive, poor prognostic human cancers,...
ORGANISM(S): Mus musculus 
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