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ProteomicsImmunogenic noncoding cryptic peptides dominate the antigenic landscape of ovarian cancer
Increased infiltration of CD3+ and CD8+ T cells into ovarian cancer (OC) tumors is linked to better prognosis, but the specific antigens involved are unclear. Recent data suggests that HLA-I can present peptides from noncoding genomic regions, known as noncanonical or cryptic peptides, but their imm...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD055609 | Pride
Immunopeptidomics Proteogenomics Noncanonical peptides Neoantigens 
ProteomicsA neurotoxic cryptic peptide arising from TDP-43-dependent cryptic splicing of PKN1
Transactive response DNA-binding protein 43 (TDP-43) is a key factor in maintaining the fidelity of neuronal RNA splicing, and its dysfunction is observed in amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) with TDP-43 pathology. Although loss of TDP-43 can activate multiple cryptic ...
ORGANISM(S): Mus Musculus 
2025-10-11 | PXD069368 |
UnknownImmunogenic cryptic peptides dominate the antigenic landscape of ovarian cancer.
Not available
S-EPMC11837991 | biostudies-literature
ProteomicsProteomic analysis of undescended testis
A total of 62022 unique peptides were acquired, and 7137 proteins were confidently identified and quantified inthe cryptic (CT) and contralateral (CLT) testis from four unilaterally cryptorchid rams
ORGANISM(S): Ovis Aries 
2024-12-19 | PXD059032 |
ProteomicsGlobal proteogenomic analysis of human MHC I peptides derived from noncanonical reading frames
Using highthroughput mass spectrometry, we probed the sixreadingframe translation of human B cells’ transcriptome. We report that about 10% of MHC Iassociated peptides (MAPs) derive from noncanonical reading frames. These socalled cryptic MAPs originate from allegedly non- coding genomic sequences ...
ORGANISM(S): Homo sapiens (Human) 
2016-01-28 | PXD001898 | Pride
Proteogenomic cryptic mhc lc-msms maps 
UnknownA distinct translation initiation mechanism generates cryptic peptides for immune surveillance.
Not available
S-EPMC2565129 | biostudies-literature
UnknownPresentation of Cryptic Peptides by MHC Class I Is Enhanced by Inflammatory Stimuli.
Not available
S-EPMC5101130 | biostudies-literature
ProteomicsIdentification of novel canonical and cryptic HCMV-specific T cell epitopes
Infection or reactivation with human cytomegalovirus (HCMV) is still a major cause of morbidity and mortality in patients undergoing solid organ transplantation or allogeneic stem cell transplantation (alloSCT). Recent studies have shown that protection against latent HCMV infection relies on a much...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2024-06-16 | PXD043022 | Pride
Hcmv Immunopeptidomics Hla peptides 
ProteomicsCancer-restricted cryptic antigens are targets for T cell recognition
Ely ZA, Kulstad ZJ, Gunaydin G, Addepalli S, Verzani EK, Casarrubios M, Clauser KR, Wang X, Lippincott IE, Louvet C, Schmitt T, Kapner KS, Agus MP, Hennessey CJ, Cleary JM, Hadrup SR, Klaeger S, Su J, Jaeger AM, Wolpin BM, Raghavan S, Smith EL, Greenberg PD, Aguirre AJ, Abelin JG, Carr SA, Jacks T, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-01-15 | MSV000096853 | MassIVE
GenomicsTumor-specific cicrRNAs elicit anti-tumor immune response via encoding cryptic peptides
Tumor-specific cicrRNAs elicit anti-tumor immune response via encoding cryptic peptides
PRJNA867553 | ENA
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