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UnknownComputational Studies on the Inhibitor Selectivity of Human JAMM Deubiquitinylases Rpn11 and CSN5.
Not available
S-EPMC6189316 | biostudies-literature
UnknownPrognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer.
Not available
S-EPMC9359627 | biostudies-literature
UnknownCSN5 overexpression promotes the integral progression of cervical cancer by enhancing ENO3-mediated glycolysis.
Not available
S-EPMC12795886 | biostudies-literature
UnknownMacrophage-derived CCL5 facilitates immune escape of colorectal cancer cells via the p65/STAT3-CSN5-PD-L1 pathway.
Not available
S-EPMC7244707 | biostudies-literature
TranscriptomicsGOLM1 dictates acquired Lenvatinib resistance by a GOLM1-CSN5 positive feedback loop upon EGFR signaling activation in hepatocellular carcinoma
Lenvatinib is a multiple receptor tyrosine kinases inhibitor (TKI) authorized for first-line treatment of hepatocellular carcinoma (HCC). However, Lenvatinib resistance is common in HCC clinical treatment, highlighting the urgent need to understand mechanisms of resistance. Here, we identified Golgi...
ORGANISM(S): Homo sapiens 
2024-08-07 | GSE273819 | GEO
TranscriptomicsThe Central Role of c-Myc during Malignant Conversion in Human Hepatocarcinogenesis
Hepatocarcinogenesis is a multi-stage process in which precursor lesions progress into early hepatocellular carcinomas (eHCC) by sequential accumulation of multiple genetic and epigenetic alterations. To decode the molecular events during early stages of liver carcinogenesis, we performed gene expre...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-12443 | biostudies-arrayexpress
GenomicsGOLM1 dictates acquired Lenvatinib resistance by a GOLM1-CSN5 positive feedback loop upon EGFR signaling activation in hepatocellular carcinoma
GOLM1 dictates acquired Lenvatinib resistance by a GOLM1-CSN5 positive feedback loop upon EGFR signaling activation in hepatocellular carcinoma
PRJNA1143404 | ENA
ProteomicsThe COP9 signalosome reduces neuroinflammation and attenuates ischemic neuronal stress in organotypic brain slice culture model
In the context of studying the role of the COP9 signalosome (CSN) in neuroinflammation and ischemic neuronal damage, we studied the effect of the cullin NEDDylation state-modifying drugs MLN4924 and CSN5i-3 in BV2 microglial cells, an immortalized murine cell line featuring many of the characteristi...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD044650 | Pride
Constitutive photomorphogenesis 9 signalosome (csn) Ischemic stroke Jab1 Csn5 Microglia Organoid 
UnknownBerberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5.
Not available
S-EPMC7745128 | biostudies-literature
ProteomicsDeubiquitinase Vulnerabilities Identified through Activity Based Protein Profiling in Non-Small Cell Lung Cancer
To aid in the prioritization of deubiquitinases (DUBs) as anticancer targets, we developed an approach combining activity-based protein profiling (ABPP) with mass spectrometry in both non-small cell lung cancer (NSCLC) tumor tissues and cell lines along with analysis of available RNA interference an...
ORGANISM(S): Homo sapiens (Human) 
2022-07-05 | PXD028802 | Pride
Human Activity-based protein profiling Deubiquitinase Lung cancer 
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