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TranscriptomicsMyeloid derived suppressor cells enhance stemness of cancer cells by inducing miRNA101 and suppressing the corepressor CtBP2
The work identifies an immune associated cellular, molecular and clinical network involving MDSCs-microRNA101-CtBP2-stem cell core genes, which extrinsically controls cancer stemness and impacts patient outcome. Primary ovarian cancer cells (5 x105) were co-cultured with freshly sorted ovarian cance...
ORGANISM(S): Homo sapiens 
2013-08-23 | E-GEOD-50082 | biostudies-arrayexpress
TranscriptomicsThe role of AR-associated factors in androgen signaling
Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation. We identified androgen-regulated genes, CTBP2, FOXP1 and RUNX1. These factors interact with AR ligand dependently. In order to investigate androgen-regulated gene functions in pr...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-58309 | biostudies-arrayexpress
GenomicsLiver transcriptome regulated by CtBP2
Liver transcriptome regulated by CtBP2
PRJNA526541 | ENA
TranscriptomicsGenome wide expression analysis of Ctbp2 knock down mouse F9 cells
Using an RNA interference-based genetic screen in mouse F9 cells we identify the transcriptional corepressor CTBP2 as a coactivator critically required for retinoic acid (RA)-induced transcription. Here we perfom a whole genome transcriptome analysis in F9 cells expressing shRNA for Ctbp2 and Rxr in...
ORGANISM(S): Mus musculus 
2013-06-21 | E-GEOD-47708 | biostudies-arrayexpress
Proteomicsproteome analysis of exosomes from WT CtBP2-HA knock-in and Mut CtBP2-HA knock-in MEF cells
We prepared two types of MEF cells: one is cells with wild-type CtBP2-HA knock-in and the other is Rossmann fold mutant CtBP2-HA knock-in. We isolated exosomes from those cells with the polymer precipitation method and subjected them to proteome analysis.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-13 | PXD066696 | Pride
Ctbp2 Exosome 
GenomicsCtBP2 ChIP-seq normal mouse liver
CtBP2 ChIP-seq normal mouse liver
PRJNA525001 | ENA
GenomicsMIN6 beta cell CtBP2 ChIP-seq
MIN6 beta cell CtBP2 ChIP-seq
PRJNA913647 | ENA
GenomicsChIP_seq
Ctbp2 regulates exit from pluripotency via silencing of embryonic stem cell active genes during differentiation. We mapped the genome-wide occupancy of Ctbp2 by ChIP-seq in mESC (E14).
ORGANISM(S): Mus musculus 
2015-06-30 | E-MTAB-2002 | biostudies-arrayexpress
GenomicsCtBP2 beta cell KO islet RNA-seq
CtBP2 beta cell KO islet RNA-seq
PRJNA913646 | ENA
TranscriptomicsE14RNA-seq
Ctbp2 regulates exit from pluripotency via silencing of embryonic stem cell active genes during differentiation. Gene expression profiles were analyzed for wild-type and Ctbp2-knockdown ESCs at both fferentiated(+LIF) and undifferentiated(-LIF) state.
ORGANISM(S): Mus musculus 
2014-12-31 | E-MTAB-2030 | biostudies-arrayexpress
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