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TranscriptomicsRNA polymerase II termination involves CTD tyrosine dephosphorylation by CPF subunit Glc7
At the 3'-ends of genes, RNA polymerase (Pol) II is dephosphorylated at tyrosine 1 residues of its C-terminal domain (CTD), resulting in recruitment of transcription termination factors. We show that the multisubunit cleavage and polyadenylation factor (CPF) is a Pol II CTD phosphatase and its Glc7 ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-16 | E-MTAB-1528 | biostudies-arrayexpress
TranscriptomicsThreonine-4 of the budding yeast RNAP II CTD couples transcription with Htz1-mediated chromatin remodeling
The C-terminal domain (CTD) of the largest subunit of RNA polymerase II (RNAP II) consists of repeated YSPTSPS heptapeptides and connects transcription with cotranscriptional events. Threonine-4 (Thr4) of the CTD repeats has been shown to function in histone mRNA 3'-end processing in chicken cells a...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-08 | E-GEOD-60181 | biostudies-arrayexpress
UnknownRpb4/7 facilitates RNA polymerase II CTD dephosphorylation.
Not available
S-EPMC4267648 | biostudies-literature
TranscriptomicsA Universal RNA Polymerase II CTD Cycle Is Orchestrated by Complex Interplays Between Kinase, Phosphatase and Isomerase Enzymes Along Genes
Transcription by RNA polymerase II (RNAPII) is coupled to mRNA processing and chromatin modifications via the C-terminal domain (CTD) of its largest subunit, consisting of multiple repeats of the heptapeptide YSPTSPS. Pioneering studies showed that CTD serines are differentially phosphorylated along...
ORGANISM(S): Saccharomyces cerevisiae 
2012-02-01 | E-GEOD-29403 | biostudies-arrayexpress
TranscriptomicsTOX4 Facilitates Promoter-Proximal Pausing and C-Terminal Domain Dephosphorylation of RNA Polymerase II in Human Cells
TOX4 is one of the regulatory proteins of PP1 phosphatases with poorly understood functions. Here we show that chromatin occupancy pattern of TOX4 resembles that of RNA polymerase II (Pol II), and its loss increases cellular level of C-terminal domain (CTD) phosphorylated Pol II but mainly decreases...
ORGANISM(S): Homo sapiens 
2022-03-29 | GSE164277 | GEO
UnknownStructural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription.
Not available
S-EPMC6544836 | biostudies-literature
GenomicsTOX4 Facilitates Promoter-Proximal Pausing and C-Terminal Domain Dephosphorylation of RNA Polymerase II in Human Cells
TOX4 Facilitates Promoter-Proximal Pausing and C-Terminal Domain Dephosphorylation of RNA Polymerase II in Human Cells
PRJNA689787 | ENA
ProteomicsPP1/PNUTS phosphatase binds the restrictor complex and stimulates RNA pol II transcription termination
The restrictor, ZC3H4/WDR82, terminates antisense transcription from bidirectional promoters, but its mechanism is poorly understood. We report that ZC3H4/WDR82 immunoprecipitate with PP1 phosphatase and its nuclear targeting subunit, PNUTS, which binds to WDR82. AlphaFold predicts a complex of PP1/...
ORGANISM(S): Homo sapiens (Human) 
2025-04-06 | PXD061598 | Pride
Pp1 phosphatase Ctd dephosphorylation Zc3h4 Pol ii ctd ser5 phosphorylation Restrictor Wdr82 Transcription termination Transcription elongation 
UnknownDeterminants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1.
Not available
S-EPMC2859291 | biostudies-literature
UnknownOxidative stress induces Ser 2 dephosphorylation of the RNA polymerase II CTD and premature transcription termination.
Not available
S-EPMC9208776 | biostudies-literature
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