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ProteomicsmTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase
Supporting MS data for paper (DOI:10.1016/j.celrep.2024.115179) by Pham, B. et al., titled "mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase". Related to Table S1 - HEK293 - degradomics (HA-2-165 | Unimod:35; 2016; 4 | 126 - Neg Ctrl (WT cells...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-29 | MSV000095724 | MassIVE
ProteomicsUbiquitylation by the GID/CTLH complex regulates the metabolic and innate immune response of macrophages to infection by Mycobacterium tuberculosis
The GID/CTLH E3 ligase complex is implicated in several biological processes, yet its full substrate repertoire remains poorly defined. We recently identified the complex as a broad modulator of macrophage responses to Mycobacterium tuberculosis (Mtb) infection. Here, we use label-free proteomics a...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-24 | PXD075792 | Pride
Metabolism Innate immunity Ubiquitylation Tuberculosis Gid/ctlh complex Macrophages 
GenomicsGenome-wide screen of Mycobacterium tuberculosis-infected macrophages revealed GID/CTLH complex-mediated modulation of bacterial growth
Genome-wide screen of Mycobacterium tuberculosis-infected macrophages revealed GID/CTLH complex-mediated modulation of bacterial growth
PRJNA1109426 | ENA
ProteomicsDifferential UBE2H-CTLH E2-E3 ubiquitylation modulesregulate erythroid maturation
The developmentof haematopoietic stem cellsinto mature erythrocytes–erythropoiesis –is a controlled process characterized by cellular reorganisation and drastic reshaping of the proteome landscape.Failure of ordered erythropoiesis isassociated with anaemias and haematological maligna...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031992 | Pride
Ube2h Proteomics Dia Ms Gid complex Ubiquitination E2 Ctlh complex E3 
UnknownRegulation of c-Raf Stability through the CTLH Complex.
Not available
S-EPMC6412545 | biostudies-literature
GenomicsUbiquitylation by the GID/CTLH complex regulates the metabolic and innate immune response of macrophages to infection by Mycobacterium tuberculosis
Ubiquitylation by the GID/CTLH complex regulates the metabolic and innate immune response of macrophages to infection by Mycobacterium tuberculosis
PRJNA1438494 | ENA
TranscriptomicsGenome-wide screen of Mycobacterium tuberculosis-infected macrophages revealed GID/CTLH complex-mediated modulation of bacterial growth
The eukaryotic GID/CTLH complex is a highly conserved E3 ubiquitin ligase involved in a broad range of biological processes. However, a role of this complex in host antimicrobial defenses has not been described. We exploited Mycobacterium tuberculosis (Mtb) induced cytotoxicity in macrophages in a F...
ORGANISM(S): Mycobacterium tuberculosis Mus musculus 
2024-05-08 | GSE267063 | GEO
UnknownThe CTLH Complex in Cancer Cell Plasticity.
Not available
S-EPMC6907057 | biostudies-literature
UnknownRanBP9 controls the oligomeric state of CTLH complex assemblies.
Not available
S-EPMC9932110 | biostudies-literature
ProteomicsGlobal and diGLY enriched proteomes of RanBPM depleted HeLa cells and RanBPM APMS
The human CTLH complex is a newly discovered multi-subunit E3 ligase. At present, only a few of its ubiquitination targets are known. Here, we use proteomic techniques in RanBPM-depleted HeLa cells to identify ubiquitination substrates of the CTLH complex. First, global proteomics determined protein...
ORGANISM(S): Homo sapiens (Human) 
2021-08-13 | PXD024872 | Pride
Human Hela Ctlh complex 
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