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TranscriptomicsRNA-seq of Arabidopsis spl7 identifies two genes required for copper acquisition and a copper dependence of iron homeostasis
The transition metal copper (Cu) is an essential element for all living organisms. In plants, Cu plays key roles in electron transport chains of chloroplasts and mitochondria, as well as in cell wall metabolism, ethylene perception, molybdenum cofactor synthesis and oxidative stress protection. Beca...
ORGANISM(S): Arabidopsis thaliana 
2013-10-14 | E-GEOD-24696 | biostudies-arrayexpress
ProteomicsArabidopsis AGO1 interactome under Cu deficiency and Cu sufficiency
In this project we look for AGO1 protein interactors in pAGO1-TST-AGO1 (Col-0) transgenic plants grown under Cu deficiency or under cu sufficiency. TST-AGO1 complexes were affinity purified and proteins were identified by tandem MS.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-11-17 | PXD057108 | Pride
Cu Arabidopsis Ago1 
TranscriptomicsThe Arabidopsis copper transport protein COPT2 and the responses under copper and iron deficiency.
Copper and iron are essential micronutrients for most living organisms because they participate as cofactors in biological processes including respiration, photosynthesis and oxidative stress protection. In many eukaryotic organisms, including yeast and mammals, copper and iron homeostases are highl...
ORGANISM(S): Arabidopsis thaliana 
2013-06-05 | E-GEOD-42642 | biostudies-arrayexpress
TranscriptomicsSystems analysis of Chlamydomonas Cu nutrition reveals connections between Cu and multiple O2-dependent metabolic steps
We used digital gene expression (NlaIII sequence tags) and RNA-Seq to compare the transcriptomes of Cu-replete vs. Cu–deficient Chlamydomonas wild-type cells to reveal dozens of mRNAs whose abundance is modified. Half of the corresponding genes are targets of CRR1, a master regulator of nutritional ...
ORGANISM(S): Chlamydomonas reinhardtii 
2011-10-23 | E-GEOD-25124 | biostudies-arrayexpress
ProteomicsProtein stability changes reveal targets of pyrithione-induced Cu toxicity in E. coli
The biological activities of metals and ionophores have brought them to the forefront as potent antimicrobial and anticancer agents. However, the biological mechanisms behind these activities are not well understood. This work describes the first utilization of proteome-wide measurements of protein ...
ORGANISM(S): Escherichia coli 
2020-12-08 | PXD021198 | Pride
Cu toxicity Protein stability Pyrithione E. coli 
no omics definedTranscription profiling of copper-stressed Pseudomonas aeruginosa
Anthropogenic pollution has increased the levels of heavy metals in the environment. Bacterial populations continue to thrive in highly polluted environments and bacteria must have mechanisms to counter heavy metal stress. We chose to examine the response of the environmentally-relevant organism P...
ORGANISM(S): Pseudomonas aeruginosa 
2007-10-24 | E-GEOD-4152 | biostudies-arrayexpress
ProteomicsCopper stress-induced changes in leaf soluble proteome of Cu-sensitive and tolerant Agrostis capillaris L. populations
Changes in leaf soluble proteome were explored in 3-month-old plants of Cu-tolerant (metallicolous, M) and sensitive (non-metallicolous, NM) Agrostis capillaris L. populations exposed to increasing Cu concentrations (1-50 µM). Aims of the study were to investigate (1) differential protein expression...
ORGANISM(S): Agrostis capillaris (Colonial bentgrass) (Agrostis tenuis) 
2016-04-12 | PXD001930 | Pride
Plant proteomics  lc-ms/ms  agrostis capillaris  cu-tolerance  photosynthesis  heat-shock protein 
TranscriptomicsTranscription profiling of Arabidopsis roots after treatment with rhizotoxic ions Al, Cu, Cd and NaCl
Comparison of gene expression responses to rhizotoxic ions (Al, Cu, Cd and NaCl) in Arabidopsis roots.
ORGANISM(S): Arabidopsis thaliana 
2009-05-04 | E-MEXP-1907 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of human bronchial cells (BEAS-2B) treated with 4-40 µg/mL Cu by CuO NP and ionic Cu, and human hepatoblastoma cells (HepG2) treated with 4-40 µg/mL ionic Cu compared to untreated controls
Cu is an essential trace element for the human body, and moreover, increasingly used in industry and clinical applications due to many favorable characteristics of this transition metal. In this context, it has been shown that CuO NP are more toxic than, e.g., CuO MP or ionic copper. Nevertheless, d...
ORGANISM(S): Homo sapiens 
2026-05-24 | E-MTAB-16794 | biostudies-arrayexpress
GenomicsChIP Seq analysis of the Cu metalloregulatory transcription factor Cuf1 in Cryptococcus neoformans in response to Cu availability
ChIP Seq analysis of the Cu metalloregulatory transcription factor Cuf1 in Cryptococcus neoformans in response to Cu availability
PRJNA432922 | ENA
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