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TranscriptomicsE2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Ubiquitin and ubiquitin-like proteins (UBLs) are directed to targets by cascades of E1, E2, and E3 enzymes. The largest ubiquitin E3 subclass consists of cullin-RING ligases (CRLs), which contain one each of several cullins (CUL1, -2, -3, -4, or -5) and RING proteins (RBX1 or -2). CRLs are activated...
ORGANISM(S): Mus musculus 
2009-03-23 | E-GEOD-14088 | biostudies-arrayexpress
ProteomicsA cullin-RING ubiquitin ligase promotes thermotolerance as part of the Intracellular Pathogen Response in C. elegans.
Intracellular pathogen infection leads to proteotoxic stress in host organisms. Previously we described a physiological program in the nematode C. elegans called the Intracellular Pathogen Response (IPR), which promotes resistance to proteotoxic stress and appears to be distinct from canonical prote...
ORGANISM(S): Caenorhabditis Elegans (ncbitaxon:6239) 
2020-02-07 | MSV000084936 | MassIVE
ProteomicsCharacterisation of cullin E3 ubiquitin ligases in trypanosomes
Trypanosomes have seven cullin paralogs, the majority lineage-specific. Six of those cullins (TbCul-A, TbCul-C, TbCul-D TbCul-E, TbCul-F and TbCul-G) were endogenously 3xHA-epitope tagged at the C-terminus. We used affinity capture/mass spectrometry to determine the composition of these cullin compl...
ORGANISM(S): Trypanosoma brucei 
2024-03-25 | PXD042022 | Pride
Cullin Evolution Affinity isolation Protein turnover Ubiquitin Cryomilling E3 ligase 
ProteomicsActivity-based profiling of cullin-RING ligase networks by conformation-specific probes
The cullin-RING E3 ligase (CRL) network comprises over 300 unique complexes that switch from inactive to activated conformations upon site-specific cullin modification by the ubiquitin-like protein NEDD8. Assessing cellular repertoires of activated CRL complexes is critical for understanding eukaryo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-09-02 | PXD039649 | Pride
Ligase Cullin Nedd8 Ring Ubiquitin E3 
TranscriptomicsDepletion of the Cullin Cdc53p Induces Morphogenetic Changes in Candida albicans
Transcriptional profiling of CDC53 down-regulated Candida albicans cells compared to control cells Keywords: comparative genomic hybridization, genetic modification Candida albicans is an important opportunistic human fungal pathogen, which can cause mucosal as well as systemic infections in immun...
ORGANISM(S): Candida albicans 
2010-05-14 | E-GEOD-13976 | biostudies-arrayexpress
ProteomicsA comparative analysis of the interactomes of viral accessory proteins exploiting DDB1 and Cullin Ubiquitin ligases
Viruses have an ambivalent relationship with the host proteome. While several host proteins are indispensable for replication, detrimental restriction factors need to be antagonized. This process is frequently catalysed by viral accessory proteins which exploit the ubiquitin proteasome pathway, DDB1...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-13 | MSV000085095 | MassIVE
ProteomicsA comparative analysis of the interactomes of viral accessory proteins exploiting DDB1 and Cullin Ubiquitin ligases
Viruses have an ambivalent relationship with the host proteome. While several host proteins are indispensable for replication, detrimental restriction factors need to be antagonized. This process is frequently catalysed by viral accessory proteins which exploit the ubiquitin proteasome pathway, DDB1...
ORGANISM(S): Homo sapiens (Human) 
2019-01-14 | PXD007634 | Pride
Proteomics Mass spectrometry Cullin ubiquitin ligases Ddb1 Viral interactome analysis 
UnknownCullin 2-RBX1 E3 ligase and USP2 regulate antithrombin ubiquitination and stability.
Not available
S-EPMC9753150 | biostudies-literature
TranscriptomicsE2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Ubiquitin and ubiquitin-like proteins (UBLs) are directed to targets by cascades of E1, E2, and E3 enzymes. The largest ubiquitin E3 subclass consists of cullin-RING ligases (CRLs), which contain one each of several cullins (CUL1, -2, -3, -4, or -5) and RING proteins (RBX1 or -2). CRLs are activated...
ORGANISM(S): Mus musculus 
2009-03-24 | GSE14088 | GEO
ProteomicsDifferential expression of proteins in hematopoietic stem/progenitor cells lacking the Cullin-5 protein
Cullin proteins are scaffolds that coordinate assembly of cullin-RING E3 ubiquitin (Ub) ligases (CRL), complexes that control post-translational ubiquitin modification and degradation of cellular proteins. Cullin-5 (Cul5) coordinates assembly of CRL complexes containing the RING E3 ligase Rbx1/2, th...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-26 | PXD051430 | Pride
Cullin-5 Hematopietic stem and progenitor cells  lsk cells 
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