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Alterations of protein abundance and post-translational modifications in patients with Alzheimer’s disease (AD), such as glycosylation, phosphorylation, and ubiquitination, and their roles in disease progression and treatment outcome are areas of intense study. Little is known, however, about...
ORGANISM(S): Homo sapiens (Human) 
2022-10-31 | PXD032219 | Pride
The macrophage mannose receptor (CD206, MR) is an endocytic lectin receptor which plays an important role in homeostasis and innate immunity. The MR contains C-type lectin domains (CTLD) whose specificity for endogenous glycans and glycoprotein ligands have not been well studied. To gain more insig...
ORGANISM(S): Homo sapiens (Human) 
2022-06-21 | PXD022546 | Pride
To explore the influence of glycosylation on mannose receptor (MR) binding to glycan ligands, we used the mouse CTLD4-7, fused to the Fc-portion of human IgG (MR-Fc) and human full-length MR. A detailed N- and O-glycopeptide analysis was performed using tryptic glycopeptides. In addition the samples...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-03-11 | PXD034781 | Pride
We utilized a high throughput discovery-based proteomics platform to identify serum peptides and proteins that were associated with the attainment of longevity in a longitudinal study of community-dwelling men age 65 years or older. Baseline serum in 1196 men were analyzed using liquid chromatograph...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-06-19 | MSV000085611 | MassIVE
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