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ProteomicsProteomics analyses of immature (21 day post infection) Fasciola hepatica
The major pathogenesis associated with Fasciola hepatica infection results from the extensive tissue damage caused by the tunnelling and feeding activity of immature flukes during their migration, growth and development in the liver. This is compounded by the pathology caused by host innate and adap...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2021-09-09 | PXD021221 | Pride
Fasciola hepatica Lc-ms-ms Growth Liver Somatic proteome Secretome 
ProteomicsCharacterization of Fasciola heptica extracellular vesicles recovered by gravity flow
Parasite-derived extracellular vesicles (EVs) are now at the forefront of helminth research, with evidence indicating that they exhibit immune modulatory activity, presenting a strong case to look at their potential as vaccine candidates. In the present study, Fasciola hepatica derived EVs (FhEVs) w...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2021-09-09 | PXD016561 | Pride
Fasciola hepatica  extracellular vesicles  excreted-secreted proteins  gravity flow 
ProteomicsAnalysis of the glycoproteins present on Fasciola hepatica surface tegument
Fasciola hepatica, commonly known as liver fluke, is a trematode which causes Fasciolosis in ruminants and humans. The outer tegumental coat of F. hepatica is a complex metabolically active biological matrix that is continually exposed to the host immune system. It is highly glycosylated and parasi...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2016-08-03 | PXD003911 | Pride
Fasciola hepatica Glycoproteins Tegument Lectin 
ProteomicsMolecular and cellular profile of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica
The liver fluke Fasciola hepatica is an economically important pathogen of livestock. Fasciolosis in humans is an important re-emerging zoonosis, with 180 million people at risk. Development of novel control strategies requires an understanding of parasite virulence and tissue invasion, and of how...
ORGANISM(S): Ovis aries 
2018-03-26 | PXD005548 | Pride
Fasciola hepatica  liver fluke  acute infection  immunopathology 
ProteomicsProteomic analysis of Fasciola hepatica somatic proteome and secretome
Background The parasite Fasciola hepatica infects a broad range of mammals with impunity. Following ingestion of parasites (metacercariae) by the host, newly excysted juveniles (NEJ) emerge from their cysts, rapidly penetrate the duodenal wall and migrate to the liver. Successful infection takes j...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2018-03-26 | PXD007255 | Pride
Fasciola hepatica Metacercariae Somatic proteome Nej Secretome Es proteins 
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