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GenomicsChIP-seq of cyclin-dependent kinases
ChIP-seq of cyclin-dependent kinases
PRJNA257298 | ENA
GenomicsChIP-seq of cyclin-dependent kinases
Several cyclin-dependent kinases (CDKs) are known to have roles in transcriptional regulation.  The datasets presented here are ChIP-seq experiments for different CDKs and RNA polymerase II in murine embryonic stem cells and Jurkat cells. ChIP-Seq of cyclin-dependent kinases in mouse embryonic stem ...
ORGANISM(S): Homo sapiens 
2014-08-03 | E-GEOD-60027 | biostudies-arrayexpress
ProteomicsCell cycle phosphorylation dynamics in vivo reveals switch-like control of intrinsic disorder
Switch-like cyclin-dependent kinase (CDK)-1 activation is thought to underlie the abruptness of mitotic onset, but how CDKs can simultaneously phosphorylate many diverse substrates is unknown, and direct evidence for such phosphorylation dynamics in vivo is lacking. Here, we analysed protein phospho...
ORGANISM(S): Xenopus Laevis 
PXD026088 | panorama
TranscriptomicsCyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network
Yeast cell cycle transcription dynamics in two S. cerevisae strains grown at 37°C: BF264-15DU (MATa ade1 his2 leu2-3, 112 trp1-1 ura3Dns, bar1) (wild type) and a mutant of the wild type strain lacking all Cdk1 activity, cdc28-4. We compared transcript levels of genes previously shown to be periodic...
ORGANISM(S): Saccharomyces cerevisiae 
2012-02-03 | E-GEOD-32974 | biostudies-arrayexpress
GenomicsChIP-seq of cyclin-dependent kinases
Several cyclin-dependent kinases (CDKs) are known to have roles in transcriptional regulation.  The datasets presented here are ChIP-seq experiments for different CDKs and RNA polymerase II in murine embryonic stem cells and Jurkat cells.
ORGANISM(S): Homo sapiens Mus musculus 
2014-08-03 | GSE60027 | GEO
ModelsGoldbeter2013-Oscillatory activity of cyclin-dependent kinases in the cell cycle
A model for oscillations of Cdc2 kinase in embryonic cell cycles based on Michaelis–Menten phosphorylation–dephosphorylation kinetics shows that the occurrence and amplitude of the oscillations strongly depend on the ultrasensitivity of the enzymatic cascade that controls the activity of the cyclin-...
2024-09-02 | BIOMD0000000944 | BioModels
ProteomicsA divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of Plasmodium berghei during gametogony and parasite transmission.
Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of divergent CDKs and cyclins of poorly understood function and interdepende...
ORGANISM(S): Plasmodium berghei ANKA 
2020-06-17 | PXD017622 | Pride
Malaria Parasite Cyclin Kinase Warwick-rtp Cyclin-dependent Plasmodium 
TranscriptomicsTranscription profiling of human peripheral blood mononuclear cells treated with a CDK inhibitor
A genomics-based approach to identify pharmacodynamic biomarkers was used for a CDK (cyclin-dependent kinase) inhibitory drug. R547 is a potent CDK inhibitor with a potent anti-proliferative effect at pharmacologically relevant doses, and is currently in Phase I clinical trials. Utilizing preclinic...
ORGANISM(S): Homo sapiens 
2009-03-28 | E-GEOD-15389 | biostudies-arrayexpress
ProteomicsA unique and divergent cyclin/cyclin-dependent kinase complex controls DNA replication during atypical cell-cycles of Plasmodium berghei gametogonyA unique and divergent cyclin/cyclin-dependent kinase complex controls DNA replication during atypical cell-cycles of Plasmodium berghei gametogony
Cell-cycle transitions are generally triggered by variations in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria parasites express ancestral CDKs and cyclins, whose functions and interdependency remain elusive. Here, we show that the unique Plasmodium berghei CDK-related kin...
ORGANISM(S): Plasmodium berghei ANKA 
2020-02-18 | PXD017283 | Pride
Lc-msms Plasmodium berhei Tmt10 Phosphorylation Cyclin-dependent kinase 
Models,MultiomicsCell Cycle Transcription by Coupled CDK and Network Oscillators
A significant fraction of the Saccharomyces cerevisiae genome is transcribed periodically during the cell division cycle, indicating that properly timed gene expression is important for regulating cell-cycle events. Genomic analyses of the localization and expression dynamics of transcription factor...
2681 | Cell Collective
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