Sort   by:  
 Page size 
MetabolomicsIsotope Labeled Reactivity-Based Metabolomics Reveal Cysteine as a Potent In Vivo Scavenger of Lactoylglutathione

Metabolite adducts are increasingly being recognized as important intermediates in cellular metabolism and as circulating messengers. Methylglyoxal (MG) is a highly reactive metabolite involved in diabetes and aging, via formation of a wide variety of protein adducts. Though new types of protein ...

2025-04-29 | MTBLS6287 | MetaboLights
ProteomicsCysteine reactivity profiling identifies host regulators of Mycobacterium tuberculosis replication in human macrophages
Innate immune cells such as monocytes and macrophages provide the earliest defense against infection by intracellular pathogens by initiating signaling pathways and restricting pathogen replication. However, the full complement of proteins that mediate cell-autonomous immunity remains incompletely d...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD067709 | Pride
Innate immunity Cysteine Macrophage Mycobacterium tuberculosis Mass spectrometry Chemical proteomics Covalent probes 
ProteomicsGlobal profiling of phosphorylation-dependent changes in cysteine reactivity
Proteomics has revealed that the ~20,000 human genes engender a far greater number of proteins, or proteoforms, that are diversified in large part by post-translational modifications (PTMs). How such PTMs affect protein structure and function is an active area of research but remains technically cha...
ORGANISM(S): Homo sapiens (Human) 
2022-03-03 | PXD026730 | Pride
Cysteine Activity-based protein profiling Tmt-abpp Mitosis Chemical proteomics Phosphorylation 
TranscriptomicsTranscription profiling of human liver cell line after cysteine deprivation
First experiment: Cells were cultured in sulfur amino acid-free DMEM supplemented with 0.1 mM methionine + 0.1 mM cysteine (complete) or supplemented only with 0.1 mM methionine (cysteine-free). Cells were cultured in either medium for 42 h (Long + Cys; Long -Cys) or in cysteine-free medium for 36 ...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9517 | biostudies-arrayexpress
ProteomicsSLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis
This study investigates how loss of the ER transporter SLC33A1 affects glutathione redox balance and protein cysteine reactivity in the endoplasmic reticulum. Oxidized cysteine reactivity profiling and whole-cell proteomics were performed in Slc33a1 knockout KPK cells and cDNA-complemented controls....
ORGANISM(S): Mus musculus (Mouse) 
2026-02-13 | PXD074382 | Pride
Glutathione Tmt proteomics Er redox Slc33a1 Cysteine reactivity Mouse cells Lc–ms/ms 
TranscriptomicsTranscription profiling of human N-Acetyl L-cysteine induced differentiation of NHEK cells in vitro
Gene expression analysis of N-Acetyl L-cysteine induced differentiation of NHEK cells in vitro.
ORGANISM(S): Homo sapiens 
2005-11-30 | E-MEXP-500 | biostudies-arrayexpress
ProteomicsDevelopment of a maleimide-based chemical proteomic method for quantitative analysis of cysteine reactivity
Cysteine is the most intrinsically nucleophilic residue in proteins and serves as a sentinel against increasing reactive oxygen species (ROS) via reversible thiol oxidation. Despite the importance of Cys oxidation in understanding biological stress response, it remains largely unknown and a major an...
ORGANISM(S): Chlamydomonas reinhardtii 
2020-10-20 | PXD015409 | Pride
Thiol-reactivity profiling Chlamydomonas reinhardtii Chemical proteomics Cysteine oxidation 
ProteomicsIsoTOP-ABPP in Jurkat cells for cysteine reactivity profiling
Cysteine reactivity in Jurkat cell lines were assessed using IsoTOP-ABPP
ORGANISM(S): Homo sapiens (Human) 
2021-02-04 | PXD022151 | Pride
Chemoproteomics Reactivity Cyteines 
UnknownIsotopically-Labeled Iodoacetamide-Alkyne Probes for Quantitative Cysteine-Reactivity Profiling.
Not available
S-EPMC5841085 | biostudies-literature
ProteomicsProteomic and cysteine reactivity profiling of the NCI-60
Proteomic and cysteine reactivity profiling of the NCI-60 human cancer cell line panel.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-07-22 | MSV000098607 | MassIVE
Sort   by:  
 Page size