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ProteomicsTMT-ABPP profiling of SP3CHO in native 293T proteome
This TMT-ABPP experiment was performed in native 293T proteome treated with a range of concentrations of SP3CHO compounds.
ORGANISM(S): Homo sapiens (Human) 
2024-06-24 | PXD051803 | Pride
Abpp Tmt Chemoproteomic 
ProteomicsTMT-ABPP cysteine profiling of SETDB1 modulators in MCF7 native proteome
We prodiled the cystene engagement of SETDB1 modulators at 10 uM in native MCF7 proteome/lysate with or without spiked of recombinant SETDB1 proteins.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056190 | Pride
Abpp Cysteine Tmt Setdb1 
ProteomicsTargeted Protein Localization by Covalent 14-3-3 Recruitment
chemoproteomic profiling of covalent ligands that target 14-3-3
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-08-28 | PXD054696 | Pride
14-3-3 
UnknownIncreasing the Throughput and Reproducibility of Activity-Based Proteome Profiling Studies with Hyperplexing and Intelligent Data Acquisition.
Not available
S-EPMC11301772 | biostudies-literature
ProteomicsGlobal profiling of phosphorylation-dependent changes in cysteine reactivity
Proteomics has revealed that the ~20,000 human genes engender a far greater number of proteins, or proteoforms, that are diversified in large part by post-translational modifications (PTMs). How such PTMs affect protein structure and function is an active area of research but remains technically cha...
ORGANISM(S): Homo sapiens (Human) 
2022-03-03 | PXD026730 | Pride
Cysteine Activity-based protein profiling Tmt-abpp Mitosis Chemical proteomics Phosphorylation 
ProteomicsIncreasing the Throughput and Reproducibility of Activity-Based Proteome Profiling Studies with Hyperplexing and Intelligent Data Acquisition
Intelligent data acquisition (IDA) strategies, such as real-time database search (RTS), have improved the depth of proteome coverage for experiments that utilize isobaric labels and gas phase purification techniques (i.e., SPS-MS3). While most applications of IDA have been focused on the analysis o...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-06-06 | MSV000092113 | MassIVE
UnknownActivity-based chemoproteomic profiling reveals the active kinome of <i>Leishmania</i>.
Not available
S-EPMC12816314 | biostudies-literature
ProteomicsProteomic Ligandability Maps of Phosphorus(V) Stereoprobes Identify Covalent TLCD1 Inhibitors
Activity-based protein profiling (ABPP) of stereoisomerically defined sets of electrophilic compounds (‘stereoprobes’) offers a versatile way to discover covalent ligands for proteins in native biological systems. Here we report the synthesis and chemical proteomic characterization of stereoprobes b...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD060339 | Pride
Lipid biology Chemical biology Chemical proteomics Electrophilic probes 
ProteomicsAltered protein cysteine reactivity in senescent cells is a vulnerability for senolysis to ameliorate aging
Diet profoundly shapes human physiology and health, including aging and age-related diseases marked by senescent cell accumulation. However, the underlying mechanisms remain unclear. Here, we report vanadyl sulfate (VS), a mineral dietary supplement, as a senolytic agent. Oral VS extends lifespan an...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-09-03 | PXD045573 | Pride
Senolysis Cysteine Vanadyl sulfate 
ProteomicsNext-Generation Multiplexed Targeted Proteomics Quantifies Post-Translational Modifications, Compound-Protein Interactions, and Disease Biomarkers with High Throughput
The GoDig platform enables sensitive, multiplexed targeted pathway proteomics without manual scheduling or synthetic standards. Here we present GoDig 2.0, which increases sample multiplexing to 35-fold, improves time efficiency and reduces scan delays for higher success rates, and allows flexible sp...
ORGANISM(S): Homo sapiens (Human) 
2026-06-25 | PXD065227 | Pride
Abpp Sample multiplexing Ptms Targeted proteomics Tmt Ubiquitylomics Reactive cysteines Phosphoproteomics Godig 
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