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ProteomicsAdapting an isobaric tag-labeled yeast peptide standard to develop targeted proteomics assays
Quantitative targeted proteomics strategies present a streamlined hypothesis-driven approach to analyze specific sets of pathways and/or disease related proteins. goDig is a targeted tandem mass tag (TMT)-based assay that can measure the expression differences for hundreds of proteins directly from ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-12-28 | PXD044397 | Pride
Tmtpro Tmt Api Targeted assay Tko Godig 
ProteomicsNext-Generation Multiplexed Targeted Proteomics Quantifies Post-Translational Modifications, Compound-Protein Interactions, and Disease Biomarkers with High Throughput
The GoDig platform enables sensitive, multiplexed targeted pathway proteomics without manual scheduling or synthetic standards. Here we present GoDig 2.0, which increases sample multiplexing to 35-fold, improves time efficiency and reduces scan delays for higher success rates, and allows flexible sp...
ORGANISM(S): Homo sapiens (Human) 
2026-06-25 | PXD065227 | Pride
Abpp Sample multiplexing Ptms Targeted proteomics Tmt Ubiquitylomics Reactive cysteines Phosphoproteomics Godig 
ProteomicsInserting Pre-Analytical Chromatographic Priming Runs Significantly Improves Targeted Pathway Proteomics With Sample Multiplexing
GoDig, a platform for targeted pathway proteomics without the need for manual assay scheduling or synthetic standards, is a powerful, flexible, and easy-to-use method that uses tandem mass tags (TMT) to increase sample throughput up to 18-fold relative to label-free methods. Though the protein-level...
ORGANISM(S): Homo sapiens (Human) 
2024-04-12 | PXD051072 | Pride
Isobaric labeling Intelligent data acquisition Macroautophagy Targeted proteomics Chromatography Instrument api Quantitative mass spectrometry Real-time search Pathway proteomics Tandem mass tags 
ProteomicsSample multiplexing-based targeted pathway proteomics with real-time analytics reveals the impact of genetic variation on protein expression
Targeted proteomics enables hypothesis-driven research by measuring the cellular expression of protein cohorts related by function, disease, or class after perturbation. Here, we present a pathway-centric approach and an assay builder resource for targeting entire pathways of proteins selected from ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2022-08-11 | MSV000090110 | MassIVE
UnknownNext-Generation Multiplexed Targeted Proteomics Quantifies Post-Translational Modifications, Compound-Protein Interactions, and Disease Biomarkers with High Throughput.
Not available
S-EPMC12458933 | biostudies-literature
UnknownAdapting an Isobaric Tag-Labeled Yeast Peptide Standard to Develop Targeted Proteomics Assays.
Not available
S-EPMC10777125 | biostudies-literature
UnknownInserting Pre-Analytical Chromatographic Priming Runs Significantly Improves Targeted Pathway Proteomics With Sample Multiplexing.
Not available
S-EPMC10871336 | biostudies-literature
UnknownInserting Pre-analytical Chromatographic Priming Runs Significantly Improves Targeted Pathway Proteomics with Sample Multiplexing.
Not available
S-EPMC11068481 | biostudies-literature
UnknownLibrary-Free Multiplexed Targeted Proteomics Enables Quantitative Protein-Level Genotyping.
Not available
S-EPMC12458936 | biostudies-literature
UnknownSample multiplexing-based targeted pathway proteomics with real-time analytics reveals the impact of genetic variation on protein expression.
Not available
S-EPMC9894840 | biostudies-literature
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