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TranscriptomicsDietary heme induces instantaneous oxidative stress but delayed cytotoxicity and compensatory hyperproliferation in mouse colon
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, injures the colon surface epithelium by luminal cytotoxicity and reactive oxygen species. This surface injury is compensated by hyperproliferation and hyperplasia of crypt cells, which was induced by a...
ORGANISM(S): Mus musculus 
2013-05-03 | E-GEOD-40671 | biostudies-arrayexpress
GenomicsCytotoxic Sigma-2 Ligands Trigger Cancer Cell Death via Cholesterol-Induced-ER-Stress
Cytotoxic Sigma-2 Ligands Trigger Cancer Cell Death via Cholesterol-Induced-ER-Stress
PRJNA1082203 | ENA
GenomicsInterrupting the nitrosative stress fuels tumor-specific cytotoxic T lymphocytes in pancreatic cancer
Interrupting the nitrosative stress fuels tumor-specific cytotoxic T lymphocytes in pancreatic cancer
PRJNA743038 | ENA
ProteomicsN7-methylguanosine methylation of tRNAs regulates survival to stress in cancer
Combining transcriptome-wide approaches to detect m7G RNA methylation, in vitro functional assays and Mettl1 knockout mouse models, we provide evidence that guanosine-7 tRNA methylation is required to protect tRNAs from cleavage in response to stress, leading to impaired regulation of protein synthe...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD036009 | Pride
Autophagy 7-methylguanosine Synthetic lethality. Prostate cancer Survival Trna fragments Epitranscriptome Senescence Cytotoxic stress 
TranscriptomicsCytotoxic Sigma-2 Ligands Trigger Cancer Cell Death via Cholesterol-Induced-ER-Stress
Sigma-2-ligands (S2L) are characterized by high-affinity interaction with their cognate sigma-2 receptor, overexpressed in rapidly proliferating tumor cells. As such, S2L were developed as imaging probes (ISO1) or as cancer therapeutics, alone (SV119 [C6], SW43 [C10]) and as delivery vehicles for cy...
ORGANISM(S): Homo sapiens 
2024-04-30 | GSE260557 | GEO
ProteomicsRegulation of the stress proteome by SCD1
Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, and induces programmed cell death. Fatty acid unsaturation prevents cytotoxic stress but the mechanisms are diffuse. We investigated changes in the proteom...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-06 | PXD025396 | Pride
Autophagy Erad Phospholipid Programmed cell death Upr Stress signaling Monounsaturated fatty acid Mouse fibroblast 
ProteomicsRegulation of stress signaling by SCD1
Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, and induces programmed cell death. Fatty acid unsaturation, controlled by stearoyl-CoA desaturase (SCD)1, prevents cytotoxic stress but the mechanisms are ...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-24 | PXD031890 | Pride
Phospholipid Stress signaling Monounsaturated fatty acid Lc-mse Mouse fibroblasts 
UnknownNorepinephrine-Activated p38 MAPK Pathway Mediates Stress-Induced Cytotoxic Edema of Basolateral Amygdala Astrocytes.
Not available
S-EPMC10887202 | biostudies-literature
ProteomicsStress Granules FUS WT e FUS P525L
Stress Granules (SG) formation is a cellular protection mechanism, constituting a storage for untranslated mRNAs and RNA-binding proteins (RBPs); however, these condensates can turn into pathological aggregates, related to the onset of neurodegenerative diseases like Amyotrophic Lateral Sclerosis (A...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049234 | Pride
Stress granules Als Rna-binding proteins Neurodegeneration Aggregation 
ProteomicsSDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species
Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs, but the mechanism of action of those potential therapeutic agents remains unknown. Using a genetic screen in haploid human cells, we discovered that the enantiospecific cytotoxicity of numerous termin...
ORGANISM(S): Homo sapiens (Human) 
2022-05-10 | PXD033059 | Pride
Cancer Isodtb Sdr enzymes Alkynylcarbinol 
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