Sort   by:  
 Page size 
ProteomicsHb Oxidation in stored RBCs and Vesicles
We used a state of the art proteomics workflow, based upon nano-UPLC-MS\MS and advanced database searching to identify oxidative modifications to functional residues of hemoglobin subunit beta . Progressive accumulation of oxidized residues in stored erythrocytes and selective removal in vesicles wa...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080222 | MassIVE
ProteomicsRed Blood Cells Serve as a Primary Glucose Sink to Improve Glucose Tolerance at Altitude
High altitude conditions improve glucose tolerance and reduce diabetes risk, but the physiological mechanism is not well-understood. Using mouse models, we found that hypoxia alone robustly improved glucose tolerance and that the effect persisted for weeks after returning to normal oxygen levels. PE...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD071719 | Pride
Red blood cells Cross-linking Hypoxia 
ProteomicsMouse BMDMs and Erythrophagocytosis LCMSMS
Reticuloendothelial macrophages engulf ~0.2 trillion senescent erythrocytes daily in a process called erythrophagocytosis (EP). This critical mechanism preserves systemic heme-iron homeostasis by regulating red blood cell (RBC) catabolism and iron recycling. Although extensive work has demonstrated ...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-27 | PXD017788 | Pride
Mouse Rbcs Bmdms Lcmsms 
ProteomicsHb Oxidation in stored RBCs and Vesicles
We used a state of the art proteomics workflow, based upon nano-UPLC-MS\MS and advanced database searching to identify oxidative modifications to functional residues of hemoglobin subunit beta . Progressive accumulation of oxidized residues in stored erythrocytes and selective removal in vesicles wa...
ORGANISM(S): Homo sapiens (Human) 
2015-10-05 | PXD002798 | Pride
Lc-ms\ms Hemoglobin Oxidation Rbc transfusion 
ProteomicsEvidence for structural protein damage and membrane lipid remodeling in red blood cells from COVID-19 patients
The SARS-CoV-2 beta coronavirus is the etiological driver of COVID-19 disease, which is primarily characterized by shortness of breath, persistent dry cough, and fever. Because they transport oxygen, red blood cells (RBCs) may play a role in the severity of hypoxemia in COVID-19 patients. The presen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-15 | MSV000086297 | MassIVE
MetabolomicsGNPS - Evidence for structural protein damage and membrane lipid remodeling in red blood cells from COVID-19 patients
The SARS-CoV-2 beta coronavirus is the etiological driver of COVID-19 disease, which is primarily characterized by shortness of breath, persistent dry cough, and fever. Because they transport oxygen, red blood cells (RBCs) may play a role in the severity of hypoxemia in COVID-19 patients. The presen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-15 | MSV000086297 | GNPS
ModelsHaiman2025 - RBC-GEM, v1.2.0, proteome-constrained
Initial submission of the proteome-constrained RBC-GEM genome-scale metabolic model, version 1.2.0. Constraints were formulated using a modified version of the OVERLAY computational pipeline (PMID: 36650525). The model is parameterized using the REDS RBC Omics dataset (PMID: 38964323). Flux bounds o...
2025-04-07 | MODEL2501130001 | BioModels
ModelsHaiman2025 - RBC-GEM v1.2.0
Initial submission of RBC-GEM genome-scale metabolic model, version 1.2.0.
2025-04-07 | MODEL2410170001 | BioModels
UnknownDNA damage contributes to neurotoxic inflammation in Aicardi-Goutieres syndrome astrocytes.
Not available
S-EPMC8916121 | biostudies-literature
ProteomicsMetabolic and Proteomic Changes in Sickle Cell Disease and thalassemia Mouse Splenic and Hepatic Macrophages and Peripheral Blood Mononuclear cells
Sickle cell disease and Beta-thalassemia represent hemoglobinopathies arising from dysfunctional or under produced beta-globin chains, respectively. In both diseases, red blood cell injury and anemia are the impetus for end organ injury. Because persistent erythrophagocytosis is a hallmark of these ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-07-17 | MSV000092457 | MassIVE
Sort   by:  
 Page size