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ProteomicsQuantitative Proteomics Revealed the Changes of Pharmacodynamic Network of Bugu Shengsui Decoction Promoting Osteoblasts Proliferation
Insufficient osteogenesis is greatly essential to osteoporosis. Bugu Shengsui Decoction, a compound formula for osteoporosis, has significant clinical effects in the treatment of osteoporosis. Yet the detailed mechanisms are unclear. In this study, we first evaluated the pharmacological effects of B...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-28 | PXD030275 | Pride
Osteoporosis Osteoblasts Bugu shengsui decoction Proliferation Quantitative proteomics Pi3k-akt Pharmacodynamic network 
ProteomicsProteomics and Metabolomics unveils Codonopsis Radix ameliorates Gastric Precancerous Lesions via regulating energy metabolism
Modern pharmacology has proved that Codonopsis Radix and its active ingredients can treat stomach diseases by ameliorating gastrointestinal motility and regulating oxidase levels. However, the detailed molecular mechanism is still unclear. In this study, we systematically evaluated the pharmacodynam...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-15 | PXD032714 | Pride
Proteomics Metabolomics Gastric precancerous lesions Serum pharmacology Energy metabolism Codonopsis radix 
ProteomicsADR-directly-interfering amino acids based on competitive isoTOP-ABPP in normoxia
Hepatocellular carcinoma (HCC) is one of the most malignant tumors in the world with high morbidity and mortality rate. Many strategies have been tried to fight with HCC, yet effective treatment is still lacking. In this study, the in vitro and in vivo anti-HCC activity of andrographolide (ADR), an ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD034583 | Pride
Andrographolide 
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