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ProteomicsGenotyping, generation and lysine 2-hydroxyisobutyrylation identification of the first human autosomal dominant osteopetrosis type II specific induced pluripotent stem cells
Background: Autosomal dominant osteopetrosis type II (ADO2) is a rare human genetic disease that has been broadly studied as an important osteopetrosis model; however, there are no disease-specific induced pluripotent stem cells (ADO2-iPSCs) that may be valuable for understanding the pathogenesis an...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD014227 | Pride
Osteopetrosis Whole exome sequencing Ipscs 2-hydroxyisobutyrylation Clcn7 
ProteomicsUSP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress
Tumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the clinical treatment of leukemia, yet it is ineffective for the treatment of solid tumors, the reasons for which remain ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-26 | PXD045622 | Pride
Usp36  snail1  ribosome biogenesis  ribotoxic stress 
ProteomicsProteomic analysis of differentially expressed proteins in the serum of patients with acute renal allograft rejection using iTRAQ labelling technology
Transplantation is currently the best treatment option for end-stage renal disease (ESRD) patients. However, acute rejection (AR) is the main source of failure in renal transplantation. The current gold standard for diagnosis of AR involves renal biopsy, but it is invasive, time consuming, costly an...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD015336 | Pride
Proteomics Acute rejection Serum Renal allograft Itraq 
ProteomicsMultiplex analyses of mitochondria in colorectal cancer patients uncover novel diagnostic and therapeutic opportunities
Background: Multi-omics analyses are profitable for discovering novel biomarkers and drug targets, but such integrated examinations on mitochondria of colorectal cancer (CRC) patients are lacking. Methods: We investigated global structural variants, DNA methylation, chromatin accessibility, proteom...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021318 | Pride
Mitochondria  multi-omics  colorectal cancer  prognosis  drug targets 
ProteomicsMultiplex analyses of mitochondria in colorectal cancer patients uncover novel diagnostic and therapeutic opportunities
Background: Multi-omics analyses are profitable for discovering novel biomarkers and drug targets, but such integrated examinations on mitochondria of colorectal cancer (CRC) patients are lacking. Methods: We investigated global structural variants, DNA methylation, chromatin accessibility, proteom...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021314 | Pride
Mitochondria  multi-omics  colorectal cancer  prognosis  drug targets 
ProteomicsComprehensive human plasma N-glycoproteome profiling based on EThcD-sceHCD-MS/MS
N-glycoproteins are involved in various biological processes. More than one-third of plasma tumor protein biomarkers approved by the Food and Drug Administration (FDA) are glycoproteins which would enhance the specificity and/or sensitivity of cancer diagnosis. Therefore, the characterization of pla...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD030622 | Pride
Mass spectrometry  human plasma  n-glycoproteomics  combinatorial peptide ligands library  ethcd-scehcd 
ProteomicsIntegrating multi-omics analyses unveil protein features of gestational diabetes mellitus and preeclampsia
As one of the most common maternal comorbidities, gestational diabetes mellitus (GDM) and preeclampsia (PE) are associated with maternal and infant health. Although the pathogenesis of PE and GDM remains controversial, oxidative stress is thought to be involved in the underlying pathology of GDM and...
ORGANISM(S): Homo sapiens (Human) 
2024-01-25 | PXD032981 | Pride
Lysine acetylation Proteomics Gestational diabetes mellitus Preeclampsia Oxidative stress 
ProteomicsA qualitative proteome-wide lysine crotonylation profiling reveals protein modification alteration in the leukocyte extravasation pathway in systemic lupus erythematosus
Background Systemic lupus erythematosus (SLE) is a severe systemic autoimmune disease with multiple manifestations. Lysine crotonylation (Kcr) is a newly discovered post-translational modification (PTM) epigenetic pattern which may affect gene expression and linked to diseases causally. Methods We ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042217 | Pride
Systemic lupus erythematosus  proteome  crotonylation  post-translational modifications  leukocyte extravasation 
ProteomicsProteome analysis of lysine 2-hydroxyisobutyrylation in the peripheral blood of systemic lupus erythematosus patients
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organs. Protein lysine modifications play important roles in gene regulation, transcription, metabolism and other biological processes. The lysine 2-hydroxyisobutyrylation(Khib) histone mark has recently been di...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD015351 | Pride
Sle  2-hydroxyisobutyrylation  mass spectrometry  bioinformatics 
ProteomicsA proteomic analysis of lysine crotonylation in systemic lupus erythematosus patients
Posttranslational modification (PTM) refers to the process of the covalent processing of translated proteins, as well as the activities and functions of proteins, and it is involved in almost all cellular pathways and processes. Lysine crotonylation (Kcr) is a recently identified PTM and plays a key...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD012966 | Pride
Posttranslational modification Lysine crotonylation Lc-ms/ms 
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