Background: Pithecellobium clypearia (PC) is a traditional Chinese medicine with anti-inflammatory effects. However, the therapeutic efficacy and underlying mechanisms of PC in ulcerative colitis (UC) remain unclear.
Objective: This study applied an integrated microbiome-meta...
Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...