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TranscriptomicsTranscription profiling of Jurkat CF4+ T cells transfected with simian immunodeficiency virus Nef cells leads to a molecular profile of viral persistence and immune evasion.
Jurkat T cell line was transfected with SIV Nef controlled by an inducible promoter system. Nef was induced by addition of 10 micromolar pronasterone A and gene expression values were determined after 24 hrs. Control Jurkat cells were untransfected and treated with 10 micromolar pronasterone A and g...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4785 | biostudies-arrayexpress
TranscriptomicsTumor biopsies from 71 untreated patients with mantle cell lymphoma
The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma Keywords: lymphochip; MCL; untreated Tumor biopsies from 71 untreated patients with mantle cell lymphoma
ORGANISM(S): Homo sapiens 
2010-05-23 | E-GEOD-10793 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis inflorescence stalks of intact plants after infection with A. tumefaciens
The intention of these gene expression analysis was to study host responses to an infection with Agrobacterium tumefaciens at different stages of crown gall development. Therefore the transcriptome of infected inflorescence stalk tissue and mature crown galls of Arabidopsis thaliana (WS-2) was deter...
ORGANISM(S): Arabidopsis thaliana 
2009-12-02 | E-GEOD-14106 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Arabidopsis after infection with different strains of Agrobacterium tumefaciens
This study focuses on responses of the host plant to infection with Agrobacterium tumefaciens. Genome wide changes in gene expression were integrated with the alterations in metabolite levels three hours after inoculation of agrobacteria. Plants were infected with the virulent strain C58, harboring ...
ORGANISM(S): Arabidopsis thaliana 
2009-12-02 | E-GEOD-13929 | biostudies-arrayexpress
ProteomicsPhagolysosomal proteomics identifies DHN-melanin-regulated processes in activated macrophage in response to Aspergillus fumigatus conidia
Infection by the human pathogenic fungus Aspergillus fumigatus is initialized by the outgrowth of asexual spores (conidia) into the lung tissue of the immunocompromised host following an inhalation of the airborne conidia. The resident phagocytes, the alveolar macrophages are the first immune cells ...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) Mus musculus (Mouse) 
2018-03-08 | PXD006134 | Pride
Host-pathogen interactions Aspergillus fumigatus Mycology Lc-ms Phagolysosome Dhn-melanin Macrophage Proteomics 
ProteomicsPhagolysosomal proteomics identifies different macrophage activation profiles in response to Aspergillus fumigatus conidia
An Aspergillus fumigatus infection is initialized by the inhalation and germination of airborne asexual spores (conidia). Alveolar macrophages are the first immune cells to counteract an infection by phagocytosis of conidia and intracellular degradation of the pathogen. However, A. fumigatus circumv...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) Mus musculus (Mouse) 
2018-03-08 | PXD005724 | Pride
Phagolysosome Macrophages Host-pathogen interaction Aspergillus fumigatus 
TranscriptomicsMetabolic modeling of antibiotic and cytotoxic effects of the isoquinoline IQ-238 in S. aureus, S. epidermidis and human cells
Isoquinolines (IQs) are natural substances with antibiotic potential. IQ-238 is a synthetic analog of the novel-type N,C-coupled naphtylisoquinoline (NIQ) alkaloid ancisheynine. Gene expression data, cytotoxicity measurements and metabolic modelling is combined to assess the effects of the N,C-coup...
ORGANISM(S): Staphylococcus aureus 
2015-04-30 | E-GEOD-33832 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis thaliana mature crown galls
This study describes physiological changes, morphological adaptations and the regulation of pathogen defense responses in Arabidopsis crown galls. Crown gall development was induced on intact plants under most natural conditions with Agrobacterium tumefaciens. Differential gene expression and the me...
ORGANISM(S): Arabidopsis thaliana 
2009-12-02 | E-GEOD-13927 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Candida albicans cells of the wildtype strain SC5314 and a sky2 deletion mutant grown on different carbon sources (glucose, malic acid, succinic acid)
RNA-sequencing was performed to investigate the role of the Candida albicans protein kinase Sky2 in metabolic adaptation to alternative carbon sources. The Candida albicans wildtype strain SC5314 and a sky2 deletion mutant were grown in medium with either glucose (3h), malic acid (6h) or succinic ac...
ORGANISM(S): Candida albicans 
2026-04-01 | E-MTAB-16222 | biostudies-arrayexpress
ProteomicsTowards zero variance in proteomics - positive pressure FASP in 96-well format (PF96) enables highly reproducible and time-efficient analysis of sample cohorts
As novel LC-MS technologies for proteomics offer substantial increase in LC-MS runs per day, robust and reproducible sample preparation emerges as a new bottleneck for throughput. We introduce a novel strategy for positive pressure 96-well filter-aided sample preparation (PF96) on a commercial posit...
ORGANISM(S): Mus Musculus 
2022-03-24 | PXD025089 | panorama
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