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TranscriptomicsTranscription profiling of human soluble guanylate cyclase-deficient U937 cells exposed to the nitric oxide (NO) donor S-nitrosoglutathione to provide insight into the cGMP-independent effects of NO
NO effects on gene expression, independent of cGMP, were examined globally. Differentiated human U937 cells that lack soluble guanylate cyclase were exposed to Snitrosoglutathione, a NO donor, or glutathione without or with dibutyryl-cAMP (Bt2cAMP). NO regulated 110 transcripts that annotated dispro...
ORGANISM(S): Homo sapiens 
2007-09-11 | E-GEOD-2649 | biostudies-arrayexpress
TranscriptomicsEffects of BMPR2 Loss in Human Pulmonary Artery Endothelial Cells
Pulmonary arterial hypertension (PAH) is a fatal disease characterized by a proliferative endothelial cell phenotype, inflammation and pulmonary vascular remodeling. BMPR2 loss-of-function has been linked to pathologic plexiform lesions with obliteration of distal pulmonary arteries distal pulmonary...
ORGANISM(S): Homo sapiens 
2015-12-04 | E-GEOD-70456 | biostudies-arrayexpress
TranscriptomicsInterfering with Proximal TLR4 to NF-kappaB Signal Transduction in Human Monocytes
This study investigated the global effect of carbon monoxide (CO) gas (250 ppm) on LPS- induced gene expression in THP-1 cells. CO predominantly suppresses LPS-induced gene response. Of the CO-suppressed genes, 18% were transcription factors and most others were cytokines, chemokines and immune resp...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-16193 | biostudies-arrayexpress
TranscriptomicsCooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes
LTB4, 50 nmol/L for 30 minutes, induced expression of 27 genes in cultured human elutriated monocytes comparred to vehicle (ethanol) treated control cells. Matched control versus treated cells
ORGANISM(S): Homo sapiens 
2011-09-20 | E-GEOD-24869 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of THP-1 cells reveals nitric oxide activation of Erk regulates the stability and translation of mRNA transcripts containing CU-rich elements
Nitric oxide (NO) can stabilize mRNA by activating p38 mitogen-activated protein kinase (MAPK). Here, transcript stabilization by NO was investigated in human THP-1 cells using microarrays. After LPS pre-stimulation, cells were treated with actinomycin D and then exposed to NO without or with the p3...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-4228 | biostudies-arrayexpress
TranscriptomicsImmune Responses to Pneumocystis Infection are Robust in Immunocompetent Mice but Absent in CD40 Ligand Deficient Mice
Pneumocystis is a pathogen of immunocompromised hosts but can also infect healthy hosts, in whom infection is rapidly controlled and cleared. To better understand the immune mechanisms contributing to clearance of infection, microarray methods were used to examine differential gene expression in the...
ORGANISM(S): Mus musculus 
2008-12-22 | E-GEOD-11005 | biostudies-arrayexpress
TranscriptomicsImpact of Animal Strain on Gene Expression in a Rat Model of Acute Cardiac Rejection
The expression levels of many genes show wide natural variation among strains or populations. This study investigated the potential for animal strain-related genotypic differences to confound gene expression profiles in acute cellular rejection (ACR). Additional analysis allowed for selection of 49 ...
ORGANISM(S): Rattus norvegicus 
2010-05-01 | E-GEOD-6342 | biostudies-arrayexpress
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