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TranscriptomicsEZH2 promotes a bi-lineage identity in basal-like breast cancer cells
The mechanisms regulating breast cancer differentiation state are poorly understood. Of particular interest are molecular regulators controlling the highly aggressive and poorly differentiated traits of basal-like breast carcinomas. Here we show that the Polycomb factor EZH2 maintains the differenti...
ORGANISM(S): Homo sapiens 
2012-09-21 | E-GEOD-36939 | biostudies-arrayexpress
UnknownNEET Proteins: A New Link Between Iron Metabolism, Reactive Oxygen Species, and Cancer.
Not available
S-EPMC10625470 | biostudies-literature
UnknownErk1<sup>R84H</sup> is an oncoprotein that causes hepatocellular carcinoma in mice and imposes a rigorous negative feedback loop.
Not available
S-EPMC12301236 | biostudies-literature
UnknownStructure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells.
Not available
S-EPMC5777063 | biostudies-literature
UnknownA VDAC1-mediated NEET protein chain transfers [2Fe-2S] clusters between the mitochondria and the cytosol and impacts mitochondrial dynamics.
Not available
S-EPMC8851467 | biostudies-literature
UnknownBreast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters.
Not available
S-EPMC5047192 | biostudies-literature
UnknownInteractions between mitoNEET and NAF-1 in cells.
Not available
S-EPMC5398536 | biostudies-literature
UnknownActivation of apoptosis in NAF-1-deficient human epithelial breast cancer cells.
Not available
S-EPMC4732299 | biostudies-literature
UnknownThe Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer.
Not available
S-EPMC4378444 | biostudies-literature
ProteomicsSimilar effects of various Erk inhibitors: interception of negative feedback, activation of p38, imposing cell cycle arrest, and maintaining cell viability
The MAP kinases Erk1/2 are the major mediators of the oncogenicity of the Receptor tyrosine kinase (RTK)-Ras-Raf-MEK cascade. As components of this pathway are often mutated and constantly active in cancer, Erks are regarded as promising targets for therapy for many types of malignancies. Yet, while...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-18 | PXD069633 | Pride
Bvd523 (ulixertinib) Map kinase Asn007 P38 Temuterkib (ly3214996) Cis-platin Mek Phosphoproteomics Sch772984 Gcd0994 (ravoxertinib) Erk 
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