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ProteomicsRole of PRMT5 in DNA damage response
Protein arginine methyltransferase (PRMT5) has emerged as a crucial symmetric dimethylating enzyme involved in the methylation of a myriad of substrates critical for epigenetic regulation, DNA damage signalling, RNA splicing, and cell fate decision. Here we have uploaded the PRMT5 interactome with t...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD057645 | Pride
Mitochondrial homeostasis Post translational modification Prmt5 Mitochondrial biogenesis Tfam Mtdna damage 
ProteomicsTDP1 phosphorylation at S61 promotes Top1cc repair via the MUS81-dependent pathway during mitosis
Topoisomerase 1 (Top1) removes supercoils from DNA during replication and transcription, is critical for mitotic progression to the G1 phase, and ensures DNA topology. Tyrosyl-DNA phosphodiesterase 1 (TDP1) mediates the removal of trapped Top1-DNA covalent complexes (Top1ccs). Here, we identify CDK1...
ORGANISM(S): Homo sapiens (Human) 
2024-06-26 | PXD053309 | Pride
Topoisomerase 1 Midas Mus81 Cdk1 Tdp1 
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