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ProteomicsLC-MS/MS identification of phosphosites at the N-terminal region of MUS81 by in vitro CHK2 kinase assay
MUS81 is a structure-specific endonuclease that processes DNA intermediates during mitosis and in S-phase following replication stress. It plays a crucial role in cleaving deprotected reversed forks in BRCA2-deficient cells. However, how MUS81 is regulated during replication stress in human cells re...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD064334 | Pride
Dna replication stress Genome instability Mus81 Brca2 
ProteomicsTDP1 phosphorylation at S61 promotes Top1cc repair via the MUS81-dependent pathway during mitosis
Topoisomerase 1 (Top1) removes supercoils from DNA during replication and transcription, is critical for mitotic progression to the G1 phase, and ensures DNA topology. Tyrosyl-DNA phosphodiesterase 1 (TDP1) mediates the removal of trapped Top1-DNA covalent complexes (Top1ccs). Here, we identify CDK1...
ORGANISM(S): Homo sapiens (Human) 
2024-06-26 | PXD053309 | Pride
Topoisomerase 1 Midas Mus81 Cdk1 Tdp1 
ProteomicsDbf4-dependent kinase (DDK) and the Rtt107 scaffold promote Mus81-Mms4 resolvase activation during mitosis
DNA repair by homologous recombination is under stringent cell cycle control. This includes the last step of the reaction, disentanglement of DNA joint molecules (JMs). Previous work has established that JMs resolving nucleases are activated specifically at the onset of mitosis. In case of budding y...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-01-21 | PXD005356 | Pride
Ddk Yeast Dna repair 
UnknownA winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes.
Not available
S-EPMC3834828 | biostudies-literature
UnknownMUS81-EME2 promotes replication fork restart.
Not available
S-EPMC5092538 | biostudies-literature
UnknownSubstrate specificity of the MUS81-EME2 structure selective endonuclease.
Not available
S-EPMC3973302 | biostudies-literature
UnknownFragment-Based Discovery of Novel MUS81 Inhibitors.
Not available
S-EPMC11247637 | biostudies-literature
UnknownSrs2 promotes Mus81-Mms4-mediated resolution of recombination intermediates.
Not available
S-EPMC4402524 | biostudies-literature
UnknownCrystal structure of the Mus81-Eme1 complex.
Not available
S-EPMC2335329 | biostudies-literature
UnknownRNA interference inhibition of Mus81 reduces mitotic recombination in human cells.
Not available
S-EPMC329235 | biostudies-literature
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