Sort   by:  
 Page size 
ProteomicsUp regulated Variant Surface Glycoproteins under TDP1 overexpression
Trypanosoma brucei parasites successfully evade the host immune system by periodically switching the dense coat of Variant Surface Glycoproteins (VSG) at the cell surface. Each parasite expresses VSGs in a monoallelic fashion that is tightly regulated. The consequences of exposing multiple VSGs duri...
ORGANISM(S): Trypanosoma brucei 
2019-09-13 | PXD014803 | Pride
Trypanosoma brucei Vsg Tdp1 
ProteomicsTDP1 phosphorylation at S61 promotes Top1cc repair via the MUS81-dependent pathway during mitosis
Topoisomerase 1 (Top1) removes supercoils from DNA during replication and transcription, is critical for mitotic progression to the G1 phase, and ensures DNA topology. Tyrosyl-DNA phosphodiesterase 1 (TDP1) mediates the removal of trapped Top1-DNA covalent complexes (Top1ccs). Here, we identify CDK1...
ORGANISM(S): Homo sapiens (Human) 
2024-06-26 | PXD053309 | Pride
Topoisomerase 1 Midas Mus81 Cdk1 Tdp1 
GenomicsTDP1 gene knockout effect on transcriptome
TDP1 gene knockout effect on transcriptome
PRJNA1037162 | ENA
GenomicsInvestigation of genetic compensation in tdp1-/- zebrafish embryos
Investigation of genetic compensation in tdp1-/- zebrafish embryos
PRJNA626551 | ENA
TranscriptomicsTDP1 gene knockout effect on transcriptome
TDP1 is an enzyme that in humans is encoded by the TDP1 gene.[5][6][7] TDP1 is the protein involved in repairing stalled topoisomerase I-DNA complexes. We evaluated the effect of Tdp1 knockout in HEK293A cells on the gene expression.
ORGANISM(S): Homo sapiens 
2023-11-20 | GSE247361 | GEO
GenomicsTranscriptional effects of TDP1 deficiency in non-replicating U2OS cells
Transcriptional effects of TDP1 deficiency in non-replicating U2OS cells
PRJNA775084 | ENA
TranscriptomicsTranscriptional effects of TDP1 deficiency in non-replicating U2OS cells
Spinocerebellar ataxia with axonal neuropathy (SCAN1) is a rare recessive neurodegenerative syndrome associated with cerebellar atrophy and peripheral neuropathy. It is caused by a homozygous missense mutation in the tyrosyl-DNA phosphodiesterase-1 (TDP1) gene (A1478G). resulting in a substitution o...
ORGANISM(S): Homo sapiens 
2024-04-30 | GSE186693 | GEO
TranscriptomicsInvestigation of genetic compensation in tdp1-/- zebrafish embryos
Tdp1, tyrosyl-DNA phosphodiesterase 1, is an enzyme responsible for the repair of DNA breaks resulting from aberrant topoisomerase 1 activity, called Top1 cleavage complexes (Top1-CCs). Mutation of Tdp1 leads to a progressive neurodegenerative disorder spinocerebellar ataxia with axonal neuropathy 1...
ORGANISM(S): Danio rerio 
2022-04-19 | GSE148923 | GEO
OtherTDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks
TDP1 removes transcription-blocking TOP1 cleavage complexes (TOP1ccs) and its inactivating H493R mutation causes the neurodegenerative syndrome SCAN1. However, the molecular mechanism underlying SCAN1 phenotype is unclear. Here, we generate human SCAN1 cell models using CRISPR/Cas9 and show that the...
ORGANISM(S): Homo sapiens 
2024-04-25 | GSE226263 | GEO
GenomicsTDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks
TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks
PRJNA939255 | ENA
Sort   by:  
 Page size