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ProteomicsCirculating tumour cells shed large extracellular vesicles in capillary-scale bifurcations
Data Independant Acquisition (DIA)-based proteomics to characaterise the proteins identified in Large Extracellular vesicles (LEVs) samples.
ORGANISM(S): Homo sapiens (Human) 
2025-09-01 | PXD050444 | Pride
Large extracellular vesicles 
ProteomicsRobust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics - Library Build, concentration response, structure activity relationships and in-cell treatment
In this manuscript we describe our work on the development of a label-free chemoproteomics screening platform for cysteine reactive covalent fragments on a 96 well plate format. Within this workflow, we profile cysteine reactive fragments by competition with the hyper-reactive iodoacetamide desthiob...
ORGANISM(S): Homo sapiens (Human) 
2024-11-18 | PXD054145 | Pride
Chemoproteomics. lavel-free quantification Data independant acquisition 
ProteomicsRobust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics - 80 compound screen (HEK293T and Jurkat)
In this manuscript we describe our work on the development of a label-free chemoproteomics screening platform for cysteine reactive covalent fragments on a 96 well plate format. Within this workflow, we profile cysteine reactive fragments by competition with the hyper-reactive iodoacetamide desthiob...
ORGANISM(S): Homo sapiens (Human) 
2024-11-18 | PXD054127 | Pride
Chemoproteomics Data independant acquisition Label-free qauntification 
ProteomicsRobust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics - HEK293T - Global expression proteomics
In this manuscript we describe our work on the development of a label-free chemoproteomics screening platform for cysteine reactive covalent fragments on a 96 well plate format. This platform profiles cysteine reactive fragments by competition with the hyper-reactive iodoacetamide desthiobiotin (IA-...
ORGANISM(S): Homo sapiens (Human) 
2024-11-18 | PXD054105 | Pride
Data independant acquistion Label free quantification 
ProteomicsLaser microdissection and proteomic study of paraffin-embedded fetal and paediatric lung tissues.
The goal of this project was to understand if lasermicrodissected epithial portions of postanatal and fetal human lung tissue could be used for proteomics, and then, further confirmed by immunostaining. The proteomic data obtained from postanatal bronchi was compared to the one obtained from alveoli...
ORGANISM(S): Homo sapiens (Human) 
2023-08-14 | PXD040654 | Pride
Ffpe  human lung  fetal tissue  lmd 
ProteomicsProtein content of extracellular vesicles from human brain microvascular endothelial cells treated by paraquat
Since the last decade, the field of extracellular vesicles (EVs) has increasingly grown. These “intracellular messengers” became interesting as biomarker source in the SNC research, because of their content, which may reflect the physiological state of their donor cells in a context of an external s...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024691 | Pride
Endothelia cells Proteomics Extracellular vesicles Dia-ms Paraquat Cns Ubiquinone metabolism Hif-1 Bbb 
ProteomicsLaser capture proteomics reveals new candidates for sperm-interacting proteins in the bovine oviduct epithelium
The proximal region of the oviduct (isthmus) serves as a sperm reservoir in many mammalian species. This reservoir is composed of epithelial cells that bind sperm primarily to their apical cilia and ensure the survival of high-quality sperm until ovulation. The species-specific molecular interaction...
ORGANISM(S): Bos taurus (Bovine) 
2025-07-28 | PXD055890 | Pride
Proteomics Oviduct epithelium Dia Cell bodies Data independant analysis Apical part Laser microdissection 
ProteomicsProteomics analysis unraveled paraquat-induced cholesterol biosynthesis dysregulation in human brain microvascular endothelial cells
Despite its banishment in several countries, Paraquat (PQ) is still one of the most commonly used herbicides in agriculture. This compound is known to induce damaging effects on human or animal brain cells such as glial cells or neurons through biological processes as redox by generation of Reactive...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026975 | Pride
Proteomics Dia Brain endothelial cells Cholesterol Paraquat Mitochondria 
MetabolomicsMetabolome of pig endometrium and placenta.

Neonatal mortality is mostly due to a reduced piglet maturity. An essential question for adaptation to extra-uterine environment lies in the optimization of the crosstalk between maternal and fetal genomes for a distribution of resources that allows fetuses to express healthier phenotypes at birt...

2025-06-30 | MTBLS3091 | MetaboLights
ProteomicsExtracellular vesicles derived from MPSIII microglia cell model impair neurite growth
Microglia is emerging as a key player in the progression of neurodegenerative diseases. In pediatric neurodegenerative diseases like mucopolysaccharidosis type III (MPSIII), the progressive accumulation of abnormal glycosaminoglycans (GAGs) induces a severe neuroinflammation by triggering a microgli...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD050768 | Pride
Gag Evs Microglia cells Mpsiii Mouse Timstof pro2 Lc-ms/ms 
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